Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328100149> ?p ?o ?g. }
- W4328100149 abstract "Left ventricular mass is a risk marker for cardiovascular events, and may indicate an underlying cardiomyopathy. Cardiac magnetic resonance is the gold-standard for left ventricular mass estimation, but is challenging to obtain at scale. Here, we use deep learning to enable genome-wide association study of cardiac magnetic resonance-derived left ventricular mass indexed to body surface area within 43,230 UK Biobank participants. We identify 12 genome-wide associations (1 known at TTN and 11 novel for left ventricular mass), implicating genes previously associated with cardiac contractility and cardiomyopathy. Cardiac magnetic resonance-derived indexed left ventricular mass is associated with incident dilated and hypertrophic cardiomyopathies, and implantable cardioverter-defibrillator implant. An indexed left ventricular mass polygenic risk score ≥90th percentile is also associated with incident implantable cardioverter-defibrillator implant in separate UK Biobank (hazard ratio 1.22, 95% CI 1.05-1.44) and Mass General Brigham (hazard ratio 1.75, 95% CI 1.12-2.74) samples. Here, we perform a genome-wide association study of cardiac magnetic resonance-derived indexed left ventricular mass to identify 11 novel variants and demonstrate that cardiac magnetic resonance-derived and genetically predicted indexed left ventricular mass are associated with incident cardiomyopathy." @default.
- W4328100149 created "2023-03-22" @default.
- W4328100149 creator A5004356613 @default.
- W4328100149 creator A5005297730 @default.
- W4328100149 creator A5006822602 @default.
- W4328100149 creator A5008444707 @default.
- W4328100149 creator A5014525847 @default.
- W4328100149 creator A5019972830 @default.
- W4328100149 creator A5032645275 @default.
- W4328100149 creator A5041028758 @default.
- W4328100149 creator A5041586675 @default.
- W4328100149 creator A5042984133 @default.
- W4328100149 creator A5043295370 @default.
- W4328100149 creator A5052881041 @default.
- W4328100149 creator A5054879244 @default.
- W4328100149 creator A5069822855 @default.
- W4328100149 creator A5077304128 @default.
- W4328100149 creator A5086482861 @default.
- W4328100149 date "2023-03-21" @default.
- W4328100149 modified "2023-10-15" @default.
- W4328100149 title "Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass" @default.
- W4328100149 cites W171827078 @default.
- W4328100149 cites W1966714873 @default.
- W4328100149 cites W1974359306 @default.
- W4328100149 cites W2003017334 @default.
- W4328100149 cites W2034972644 @default.
- W4328100149 cites W2039153962 @default.
- W4328100149 cites W2050165353 @default.
- W4328100149 cites W2052039979 @default.
- W4328100149 cites W2060072866 @default.
- W4328100149 cites W2082704080 @default.
- W4328100149 cites W2084061233 @default.
- W4328100149 cites W2101412130 @default.
- W4328100149 cites W2105923479 @default.
- W4328100149 cites W2109785413 @default.
- W4328100149 cites W2132106701 @default.
- W4328100149 cites W2134497773 @default.
- W4328100149 cites W2139884473 @default.
- W4328100149 cites W2153860431 @default.
- W4328100149 cites W2155028668 @default.
- W4328100149 cites W2167989424 @default.
- W4328100149 cites W2197160961 @default.
- W4328100149 cites W2208136915 @default.
- W4328100149 cites W2246750959 @default.
- W4328100149 cites W2258978862 @default.
- W4328100149 cites W2264343894 @default.
- W4328100149 cites W2264574558 @default.
- W4328100149 cites W2276319388 @default.
- W4328100149 cites W2417483443 @default.
- W4328100149 cites W2461646772 @default.
- W4328100149 cites W2563682840 @default.
- W4328100149 cites W2586919761 @default.
- W4328100149 cites W2604130591 @default.
- W4328100149 cites W2604500500 @default.
- W4328100149 cites W2614948710 @default.
- W4328100149 cites W2723723801 @default.
- W4328100149 cites W2746516350 @default.
- W4328100149 cites W2759086237 @default.
- W4328100149 cites W2761275051 @default.
- W4328100149 cites W2772403010 @default.
- W4328100149 cites W2782407591 @default.
- W4328100149 cites W2789833091 @default.
- W4328100149 cites W2793094728 @default.
- W4328100149 cites W2803176574 @default.
- W4328100149 cites W2807295499 @default.
- W4328100149 cites W2883415719 @default.
- W4328100149 cites W2885676239 @default.
- W4328100149 cites W2901303766 @default.
- W4328100149 cites W2903835113 @default.
- W4328100149 cites W2950598813 @default.
- W4328100149 cites W2952013316 @default.
- W4328100149 cites W2959380923 @default.
- W4328100149 cites W2970272920 @default.
- W4328100149 cites W2971955548 @default.
- W4328100149 cites W2975505463 @default.
- W4328100149 cites W2999230481 @default.
- W4328100149 cites W3021169955 @default.
- W4328100149 cites W3021263686 @default.
- W4328100149 cites W3023537913 @default.
- W4328100149 cites W3027216380 @default.
- W4328100149 cites W3028232944 @default.
- W4328100149 cites W3029661147 @default.
- W4328100149 cites W3052902836 @default.
- W4328100149 cites W3086703412 @default.
- W4328100149 cites W3121184362 @default.
- W4328100149 cites W3134184401 @default.
- W4328100149 cites W3136011252 @default.
- W4328100149 cites W3161754417 @default.
- W4328100149 cites W3187975697 @default.
- W4328100149 cites W4212853165 @default.
- W4328100149 cites W4280552086 @default.
- W4328100149 cites W4283014247 @default.
- W4328100149 cites W4285677475 @default.
- W4328100149 doi "https://doi.org/10.1038/s41467-023-37173-w" @default.
- W4328100149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36944631" @default.
- W4328100149 hasPublicationYear "2023" @default.
- W4328100149 type Work @default.
- W4328100149 citedByCount "3" @default.
- W4328100149 countsByYear W43281001492023 @default.
- W4328100149 crossrefType "journal-article" @default.