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• W4328100163 abstract "Nearly 300 years after the first description of aortic valve obstruction, it has taken less than two decades of randomized clinical trials (RCTs) for transcatheter aortic valve implantation (TAVI) to become a recognized strategy for patients with aortic stenosis. The high density of recent publications makes it easy to ignore the history that led to the development of this procedure. Knowing the evolution of a diagnostic or therapeutic technique improves critical reasoning, prevents repeated mistakes, paves the way for future research and contributes to an insightful perspective on the subject. Nevertheless, it should not overshadow the findings of recently published RCTs, which still are the mainstay of clinical practice. In this timeline review, the authors aim to recap the development of TAVI, combining the pathophysiology of aortic stenosis and the initial concept of TAVI with the roadmap of clinical trials that led to the generalization of the TAVI procedure. Após cerca de 300 anos da primeira descrição de uma obstrução da válvula aórtica, menos de duas décadas de estudos randomizados decorreram até a válvula aórtica percutânea (VAP) ser uma estratégia terapêutica reconhecida para doentes com estenose aórtica. Com a elevada densidade de estudos recentes é possível negligenciar a perspetiva histórica que originou este procedimento. Conhecer o fundamento histórico que sustenta uma técnica terapêutica ou diagnóstica melhora o raciocínio clínico, previne a repetição de erros do passado, define os estudos do futuro e permite enriquecer a perspetiva sobre o tema. No entanto, o conhecimento histórico não se deve sobrepor aos estudos randomizados mais recentes, que continuam a ser o pilar principal das decisões feitas na prática clínica. Nesta revisão temporal, pretende-se delinear uma linha temporal da história da VAP, combinando o desenvolvimento do conhecimento da patofisiologia da estenose aórtica e a sequência de descobertas que originou o conceito inicial da VAP, com o percurso de estudos clínicos que levaram à globalização deste procedimento." @default.
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• W4328100163 date "2023-08-01" @default.
• W4328100163 modified "2023-10-01" @default.
• W4328100163 title "The roadmap to transcatheter aortic valve implantation" @default.
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• W4328100163 doi "https://doi.org/10.1016/j.repc.2022.09.004" @default.
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