FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328101903> ?p ?o ?g. }

• W4328101903 endingPage "100356" @default.
• W4328101903 startingPage "100356" @default.
• W4328101903 abstract "Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer[EOS]) are essential components of the lipid skin barrier, which protects our body from excessive water loss and the penetration of unwanted substances. These ceramides drive the lipid assembly to epidermal-specific long periodicity phase (LPP), structurally much different than conventional lipid bilayers. Here, we synthesized Cer[EOS] with selectively deuterated segments of the ultralong N-acyl chain or deuterated or 13C-labeled linoleic acid and studied their molecular behavior in a skin lipid model. Solid-state 2H NMR data revealed surprising molecular dynamics for the ultralong N-acyl chain of Cer[EOS] with increased isotropic motion toward the isotropic ester-bound linoleate. The sphingosine moiety of Cer[EOS] is also highly mobile at skin temperature, in stark contrast to the other LPP components, N-lignoceroyl sphingosine acyl, lignoceric acid, and cholesterol, which are predominantly rigid. The dynamics of the linoleic chain is quantitatively described by distributions of correlation times and using dynamic detector analysis. These NMR results along with neutron diffraction data suggest an LPP structure with alternating fluid (sphingosine chain-rich), rigid (acyl chain-rich), isotropic (linoleate-rich), rigid (acyl-chain rich), and fluid layers (sphingosine chain-rich). Such an arrangement of the skin barrier lipids with rigid layers separated with two different dynamic fillings i) agrees well with ultrastructural data, ii) satisfies the need for simultaneous rigidity (to ensure low permeability) and fluidity (to ensure elasticity, accommodate enzymes, or antimicrobial peptides), and iii) offers a straightforward way to remodel the lamellar body lipids into the final lipid barrier." @default.
• W4328101903 created "2023-03-22" @default.
• W4328101903 creator A5002981124 @default.
• W4328101903 creator A5010684861 @default.
• W4328101903 creator A5024149482 @default.
• W4328101903 creator A5024885750 @default.
• W4328101903 creator A5037800103 @default.
• W4328101903 creator A5037870803 @default.
• W4328101903 creator A5055008069 @default.
• W4328101903 creator A5055666390 @default.
• W4328101903 creator A5077686729 @default.
• W4328101903 creator A5078734112 @default.
• W4328101903 creator A5085225128 @default.
• W4328101903 creator A5088666049 @default.
• W4328101903 creator A5091001354 @default.
• W4328101903 date "2023-05-01" @default.
• W4328101903 modified "2023-10-09" @default.
• W4328101903 title "The intriguing molecular dynamics of Cer[EOS] in rigid skin barrier lipid layers requires improvement of the model" @default.
• W4328101903 cites W1483228644 @default.
• W4328101903 cites W1600382534 @default.
• W4328101903 cites W1966339391 @default.
• W4328101903 cites W1970185852 @default.
• W4328101903 cites W1980478162 @default.
• W4328101903 cites W1982694916 @default.
• W4328101903 cites W1983182488 @default.
• W4328101903 cites W1987033415 @default.
• W4328101903 cites W1988201012 @default.
• W4328101903 cites W1991757508 @default.
• W4328101903 cites W1993882354 @default.
• W4328101903 cites W1993970802 @default.
• W4328101903 cites W1995093903 @default.
• W4328101903 cites W1996392766 @default.
• W4328101903 cites W1996989293 @default.
• W4328101903 cites W2000819908 @default.
• W4328101903 cites W2008276067 @default.
• W4328101903 cites W2016954164 @default.
• W4328101903 cites W2017689271 @default.
• W4328101903 cites W2018383191 @default.
• W4328101903 cites W2022593894 @default.
• W4328101903 cites W2026029590 @default.
• W4328101903 cites W2032066103 @default.
• W4328101903 cites W2033921570 @default.
• W4328101903 cites W2034781914 @default.
• W4328101903 cites W2037690008 @default.
• W4328101903 cites W2039233139 @default.
• W4328101903 cites W2041063484 @default.
• W4328101903 cites W2050741267 @default.
• W4328101903 cites W2060371764 @default.
• W4328101903 cites W2063838583 @default.
• W4328101903 cites W2065059837 @default.
• W4328101903 cites W2066594184 @default.
• W4328101903 cites W2071467620 @default.
• W4328101903 cites W2074551088 @default.
• W4328101903 cites W2080244677 @default.
• W4328101903 cites W2082125199 @default.
• W4328101903 cites W2084391850 @default.
• W4328101903 cites W2085492412 @default.
• W4328101903 cites W2094157002 @default.
• W4328101903 cites W2115244264 @default.
• W4328101903 cites W2126937934 @default.
• W4328101903 cites W2141095211 @default.
• W4328101903 cites W2141749825 @default.
• W4328101903 cites W2143928908 @default.
• W4328101903 cites W2146175931 @default.
• W4328101903 cites W2185265064 @default.
• W4328101903 cites W2193044578 @default.
• W4328101903 cites W2279669580 @default.
• W4328101903 cites W2312827011 @default.
• W4328101903 cites W2365764378 @default.
• W4328101903 cites W2565940836 @default.
• W4328101903 cites W2581762208 @default.
• W4328101903 cites W2583461346 @default.
• W4328101903 cites W2747962454 @default.
• W4328101903 cites W2756086600 @default.
• W4328101903 cites W2781521868 @default.
• W4328101903 cites W2790867044 @default.
• W4328101903 cites W2796194553 @default.
• W4328101903 cites W2799749633 @default.
• W4328101903 cites W2806089032 @default.
• W4328101903 cites W2902671824 @default.
• W4328101903 cites W2903107073 @default.
• W4328101903 cites W2911448557 @default.
• W4328101903 cites W2924087020 @default.
• W4328101903 cites W2942143261 @default.
• W4328101903 cites W297460186 @default.
• W4328101903 cites W3009814870 @default.
• W4328101903 cites W3033560681 @default.
• W4328101903 cites W328291120 @default.
• W4328101903 cites W4200622095 @default.
• W4328101903 cites W4210847301 @default.
• W4328101903 cites W4226026837 @default.
• W4328101903 cites W4280512564 @default.
• W4328101903 cites W4292236939 @default.
• W4328101903 cites W4312203633 @default.
• W4328101903 cites W4376848205 @default.
• W4328101903 doi "https://doi.org/10.1016/j.jlr.2023.100356" @default.
• W4328101903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36948272" @default.
• W4328101903 hasPublicationYear "2023" @default.

• next