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- W4328103631 endingPage "107896" @default.
- W4328103631 startingPage "107896" @default.
- W4328103631 abstract "Benzotriazole ultraviolet stabilizers (BUVSs) are emerging pollutants that are widely detected in aquatic ecosystems. While structure-dependent effects of BUVSs are reported, the relationship between biotransformation and toxicity outcomes remains unclear. In this study, zebrafish embryos were exposed to two common BUVSs (UV-234 and UV-326) at 1, 10, and 100 µg/L for up to 7 days. Comparison of their uptake and biotransformation revealed that the bioaccumulation capacity of UV-234 was higher than that of UV-326, while UV-326 was more extensively biotransformed with additional conjugation reactions. However, UV-326 showed low metabolism due to inhibited phase II enzymes, which may result in the comparable internal concentrations of both BUVSs in larval zebrafish. Both BUVSs induced oxidative stress while decreased MDA, suggesting the disturbance of lipid metabolism. The subsequent metabolomic profiling revealed that UV-234 and UV-326 exerted different effects on arachidonic acid, lipid, and energy metabolism. However, both BUVSs negatively impacted the cyclic guanosine monophosphate / protein kinase G pathway. This converged metabolic change resulted in comparable toxicity of UV-234 and UV-326, which was confirmed by the induction of downstream apoptosis, neuroinflammation, and abnormal locomotion behavior. These data have important implications for understanding the metabolism, disposition, and toxicology of BUVSs in aquatic organisms." @default.
- W4328103631 created "2023-03-22" @default.
- W4328103631 creator A5007141219 @default.
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- W4328103631 creator A5080492640 @default.
- W4328103631 date "2023-04-01" @default.
- W4328103631 modified "2023-10-14" @default.
- W4328103631 title "Biotransformation, metabolic response, and toxicity of UV-234 and UV-326 in larval zebrafish (Danio rerio)" @default.
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- W4328103631 doi "https://doi.org/10.1016/j.envint.2023.107896" @default.
- W4328103631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36966637" @default.
- W4328103631 hasPublicationYear "2023" @default.
- W4328103631 type Work @default.