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- W4328103650 endingPage "124129" @default.
- W4328103650 startingPage "124129" @default.
- W4328103650 abstract "Drug-resistant microorganisms are defeated using combinational drug delivery systems based on biopolymer chitosan (CS) and metal nanoparticles. Hence, PEGylated zinc oxide nanoparticles (P-ZnO NPs) decorated chitosan-based nanoparticles (CS NPs) were prepared to deliver ampicillin (AMP) for improved antibacterial activity. In comparison to ZnO NPs, P-ZnO NPs exhibit less aggregation and more stable rod morphologies in TEM. The size of the P-ZnO NPs decreased and was engulfed by the spherical CS-AMP NPs. The zeta potential of the CS-AMP-P-ZnO NPs was determined to be -32.93 mV and the hydrodynamic size to be 210.2 d. nm. Further, DEE and DLE of CS-AMP (2.0:0.2 w/w) showed 79.60 ± 2.62 % and 15.14 ± 2.11 %, respectively. The cumulative AMP release was observed at >50 % at 48 h at pH 5.4 and 7.4. Additionally, when compared to AMP, CS-AMP-P-ZnO NPs had better antibacterial activity against E. coli, due to the alternation of cell membrane permeability by CS and ZnO NPs. Moreover, the hemolytic properties of ZnO NPs were attenuated because of PEGylation and CS. Furthermore, due to the biocompatible behavior of CS, CS-AMP-P-ZnO NPs did not exhibit toxicity on HEK-293 cells, erythrocytes, and chick embryos. Hence, this study concludes that CS-AMP-P-ZnO NPs could be a promising antibacterial agent." @default.
- W4328103650 created "2023-03-22" @default.
- W4328103650 creator A5006651636 @default.
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- W4328103650 creator A5011447987 @default.
- W4328103650 creator A5051910998 @default.
- W4328103650 creator A5075551415 @default.
- W4328103650 date "2023-05-01" @default.
- W4328103650 modified "2023-09-29" @default.
- W4328103650 title "Ampicillin-resistant bacterial pathogens targeted chitosan nano-drug delivery system (CS-AMP-P-ZnO) for combinational antibacterial treatment" @default.
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- W4328103650 doi "https://doi.org/10.1016/j.ijbiomac.2023.124129" @default.
- W4328103650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36958450" @default.
- W4328103650 hasPublicationYear "2023" @default.
- W4328103650 type Work @default.