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• W4328103809 abstract "Acquired melanocytic nevi can be classified using dermoscopy and have previously been demonstrated to have to distinct molecular profiles ( Muse et al., 2022 Muse ME Bergman DT Salas LA Tom LN Tan JM Laino A et al. Genome-Scale DNA Methylation Analysis Identifies Repeat Element Alterations that Modulate the Genomic Stability of Melanocytic Nevi. J Invest Dermatol. 2022; 142: 1893-18902 e7 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar , Stark et al., 2018 Stark MS Tan JM Tom L Jagirdar K Lambie D Schaider H et al. Whole-Exome Sequencing of Acquired Nevi Identifies Mechanisms for Development and Maintenance of Benign Neoplasms. J Invest Dermatol. 2018; 138: 1636-1644 Abstract Full Text Full Text PDF PubMed Scopus (32) Google Scholar , Tan et al., 2018 Tan JM Tom LN Jagirdar K Lambie D Schaider H Sturm RA et al. The BRAF and NRAS mutation prevalence in dermoscopic subtypes of acquired naevi reveals constitutive mitogen-activated protein kinase pathway activation. Br J Dermatol. 2018; 178: 191-197 Crossref PubMed Scopus (22) Google Scholar ). Perilesional skin occurring adjacent to nevi is variable due to differences in skin color, body site, and sun damage which may include solar elastosis, freckling, and increase in pigmented solar lentigines (Rosendahl and Marozava, 2019). Sun-exposed skin has been found to be awash with somatic mutations ( Martincorena et al., 2015 Martincorena I Roshan A Gerstung M Ellis P Van Loo P McLaren S et al. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science. 2015; 348: 880-886 Crossref PubMed Scopus (1046) Google Scholar , Stark et al., 2018 Stark MS Tan JM Tom L Jagirdar K Lambie D Schaider H et al. Whole-Exome Sequencing of Acquired Nevi Identifies Mechanisms for Development and Maintenance of Benign Neoplasms. J Invest Dermatol. 2018; 138: 1636-1644 Abstract Full Text Full Text PDF PubMed Scopus (32) Google Scholar ), which vary according to body site ( Fowler et al., 2021 Fowler JC King C Bryant C Hall MWJ Sood R Ong SH et al. Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site. Cancer Discov. 2021; 11: 340-361 Crossref PubMed Scopus (37) Google Scholar ), and are also commonly found in cutaneous malignancies including melanoma. It has recently been described that the microenvironments for cutaneous melanomas and melanoma of acral skin exhibit different transcriptional programs that, when combined with specific somatic mutations, dictate where on the body a melanoma will form ( Weiss et al., 2022 Weiss JM Hunter MV Cruz NM Baggiolini A Tagore M Ma Y et al. Anatomic position determines oncogenic specificity in melanoma. Nature. 2022; Crossref Scopus (18) Google Scholar )." @default.
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• W4328103809 date "2023-09-01" @default.
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• W4328103809 title "Distinct HOX Gene Family DNA Methylation Profiles in Histologically Normal Skin Dependent on Dermoscopic Pattern of Adjacent Nevi" @default.
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• W4328103809 doi "https://doi.org/10.1016/j.jid.2023.03.1653" @default.
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