Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328105007> ?p ?o ?g. }
- W4328105007 abstract "Introduction: Neuronal Ca2+ signals generated through the activation of Ca2+-induced Ca2+ release in response to activity-generated Ca2+ influx play a significant role in hippocampal synaptic plasticity, spatial learning, and memory. We and others have previously reported that diverse stimulation protocols, or different memory-inducing procedures, enhance the expression of endoplasmic reticulum-resident Ca2+ release channels in rat primary hippocampal neuronal cells or hippocampal tissue. Methods and Results: Here, we report that induction of long-term potentiation (LTP) by Theta burst stimulation protocols of the CA3-CA1 hippocampal synapse increased the mRNA and protein levels of type-2 Ryanodine Receptor (RyR2) Ca2+ release channels in rat hippocampal slices. Suppression of RyR channel activity (1 h preincubation with 20 μM ryanodine) abolished both LTP induction and the enhanced expression of these channels; it also promoted an increase in the surface expression of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits GluR1 and GluR2 and caused a moderate but significant reduction of dendritic spine density. In addition, training rats in the Morris water maze induced memory consolidation, which lasted for several days after the end of the training period, accompanied by an increase in the mRNA levels and the protein content of the RyR2 channel isoform. Discussion: We confirm in this work that LTP induction by TBS protocols requires functional RyR channels. We propose that the increments in the protein content of RyR2 Ca2+ release channels, induced by LTP or spatial memory training, play a significant role in hippocampal synaptic plasticity and spatial memory consolidation." @default.
- W4328105007 created "2023-03-22" @default.
- W4328105007 creator A5001238861 @default.
- W4328105007 creator A5018600546 @default.
- W4328105007 creator A5020686637 @default.
- W4328105007 creator A5048833720 @default.
- W4328105007 creator A5052452113 @default.
- W4328105007 creator A5055084815 @default.
- W4328105007 creator A5061334070 @default.
- W4328105007 creator A5065983594 @default.
- W4328105007 creator A5072139994 @default.
- W4328105007 creator A5074690235 @default.
- W4328105007 creator A5085226826 @default.
- W4328105007 date "2023-03-21" @default.
- W4328105007 modified "2023-10-18" @default.
- W4328105007 title "Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels" @default.
- W4328105007 cites W1445716912 @default.
- W4328105007 cites W1681805371 @default.
- W4328105007 cites W1908141284 @default.
- W4328105007 cites W1922041268 @default.
- W4328105007 cites W1964761861 @default.
- W4328105007 cites W1966474756 @default.
- W4328105007 cites W1966999034 @default.
- W4328105007 cites W1968066661 @default.
- W4328105007 cites W1968986493 @default.
- W4328105007 cites W1970578796 @default.
- W4328105007 cites W1972937898 @default.
- W4328105007 cites W1984636398 @default.
- W4328105007 cites W1993536619 @default.
- W4328105007 cites W1994619899 @default.
- W4328105007 cites W1995875542 @default.
- W4328105007 cites W1998893763 @default.
- W4328105007 cites W1999719682 @default.
- W4328105007 cites W2002428093 @default.
- W4328105007 cites W2011367879 @default.
- W4328105007 cites W2014281089 @default.
- W4328105007 cites W2021073299 @default.
- W4328105007 cites W2022324453 @default.
- W4328105007 cites W2023013885 @default.
- W4328105007 cites W2024879799 @default.
- W4328105007 cites W2037676584 @default.
- W4328105007 cites W2041740826 @default.
- W4328105007 cites W2050066016 @default.
- W4328105007 cites W2050999349 @default.
- W4328105007 cites W2061066675 @default.
- W4328105007 cites W2067460742 @default.
- W4328105007 cites W2067915400 @default.
- W4328105007 cites W2073727327 @default.
- W4328105007 cites W2083514820 @default.
- W4328105007 cites W2097217313 @default.
- W4328105007 cites W2098896251 @default.
- W4328105007 cites W2120383851 @default.
- W4328105007 cites W2138420093 @default.
- W4328105007 cites W2139210491 @default.
- W4328105007 cites W2143424380 @default.
- W4328105007 cites W2171569424 @default.
- W4328105007 cites W2405029025 @default.
- W4328105007 cites W2564817968 @default.
- W4328105007 cites W2605311678 @default.
- W4328105007 cites W2608013985 @default.
- W4328105007 cites W2625495305 @default.
- W4328105007 cites W2784833873 @default.
- W4328105007 cites W2898344414 @default.
- W4328105007 cites W2899961185 @default.
- W4328105007 cites W2903388819 @default.
- W4328105007 cites W2957553017 @default.
- W4328105007 cites W3188879132 @default.
- W4328105007 cites W41460770 @default.
- W4328105007 cites W4214658194 @default.
- W4328105007 doi "https://doi.org/10.3389/fncel.2023.1132121" @default.
- W4328105007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37025696" @default.
- W4328105007 hasPublicationYear "2023" @default.
- W4328105007 type Work @default.
- W4328105007 citedByCount "2" @default.
- W4328105007 countsByYear W43281050072023 @default.
- W4328105007 crossrefType "journal-article" @default.
- W4328105007 hasAuthorship W4328105007A5001238861 @default.
- W4328105007 hasAuthorship W4328105007A5018600546 @default.
- W4328105007 hasAuthorship W4328105007A5020686637 @default.
- W4328105007 hasAuthorship W4328105007A5048833720 @default.
- W4328105007 hasAuthorship W4328105007A5052452113 @default.
- W4328105007 hasAuthorship W4328105007A5055084815 @default.
- W4328105007 hasAuthorship W4328105007A5061334070 @default.
- W4328105007 hasAuthorship W4328105007A5065983594 @default.
- W4328105007 hasAuthorship W4328105007A5072139994 @default.
- W4328105007 hasAuthorship W4328105007A5074690235 @default.
- W4328105007 hasAuthorship W4328105007A5085226826 @default.
- W4328105007 hasBestOaLocation W43281050071 @default.
- W4328105007 hasConcept C113217602 @default.
- W4328105007 hasConcept C127445978 @default.
- W4328105007 hasConcept C148762608 @default.
- W4328105007 hasConcept C158617107 @default.
- W4328105007 hasConcept C160268369 @default.
- W4328105007 hasConcept C169760540 @default.
- W4328105007 hasConcept C170493617 @default.
- W4328105007 hasConcept C174884520 @default.
- W4328105007 hasConcept C185592680 @default.
- W4328105007 hasConcept C190712762 @default.
- W4328105007 hasConcept C25274449 @default.
- W4328105007 hasConcept C2776328245 @default.