FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328105096> ?p ?o ?g. }

• W4328105096 abstract "Abstract Background Premature ovarian insufficiency (POI) is a common clinical problem, however, there are currently no effective therapies. Pyroptosis induced by the NLRP3 inflammasome is considered a possible mechanism of POI. Placental mesenchymal stem cells (PMSCs) have excellent immunomodulatory potential and offer a promising method for treating POI. Methods Female Sprague–Dawley rats were randomly divided into four treatment groups: control (no POI), POI with no PMSCs, POI with PMSCs transplant, and POI with hormones (estrogen + progesterone) as positive control. POI was induced by exposure to 4-vinylcyclohexene diepoxide (VCD) for 15 days. After four weeks, all animals were euthanized and examined for pathology. Hormone levels were measured and ovarian function was evaluated in relation to the estrous cycle. Levels of NLRP3 inflammasome pathway proteins were determined by immunohistochemistry and western blot. Results VCD significantly damaged rat follicles at different estrous stages. Injection of human PMSCs improved ovarian function and reproductive ability of POI rats compared to the sham and hormone groups. Our data also showed that PMSCs markedly suppress cell pyroptosis via downregulation of the NLRP3 inflammasome, caspase-1, IL-1β and IL-18 compared to the other two groups. The human PMSCs increased the expression of IL-4 and IL-10 and decreased pro-inflammatory factors by phenotypic changes in macrophages. Conclusions Our findings revealed a novel mechanism of follicular dysfunction and ovarian fibrosis via activation of the NLRP3 inflammasome followed by secretion of pro-inflammatory factors. Transplantation of PMSCs into POI rats suppressed pro-inflammatory factor production, NLRP3 inflammasome formation and pyroptosis, and improved ovarian function." @default.
• W4328105096 created "2023-03-22" @default.
• W4328105096 creator A5002953135 @default.
• W4328105096 creator A5015824781 @default.
• W4328105096 creator A5017695859 @default.
• W4328105096 creator A5026546306 @default.
• W4328105096 creator A5038117148 @default.
• W4328105096 creator A5038693765 @default.
• W4328105096 creator A5039523519 @default.
• W4328105096 creator A5061494260 @default.
• W4328105096 creator A5064462401 @default.
• W4328105096 creator A5074592118 @default.
• W4328105096 date "2023-03-21" @default.
• W4328105096 modified "2023-10-18" @default.
• W4328105096 title "Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization" @default.
• W4328105096 cites W1985538633 @default.
• W4328105096 cites W1985750206 @default.
• W4328105096 cites W2048032544 @default.
• W4328105096 cites W2118918019 @default.
• W4328105096 cites W2252567929 @default.
• W4328105096 cites W2255032699 @default.
• W4328105096 cites W2775870439 @default.
• W4328105096 cites W2810536477 @default.
• W4328105096 cites W2883435196 @default.
• W4328105096 cites W3007217411 @default.
• W4328105096 cites W3043831833 @default.
• W4328105096 cites W3090696777 @default.
• W4328105096 cites W3091857028 @default.
• W4328105096 cites W3111866599 @default.
• W4328105096 cites W3120028415 @default.
• W4328105096 cites W3127796583 @default.
• W4328105096 cites W3131434927 @default.
• W4328105096 cites W3157069379 @default.
• W4328105096 cites W3161448449 @default.
• W4328105096 cites W3162715207 @default.
• W4328105096 cites W3175500804 @default.
• W4328105096 cites W3190251030 @default.
• W4328105096 cites W3191851278 @default.
• W4328105096 cites W3195112154 @default.
• W4328105096 cites W3196131466 @default.
• W4328105096 cites W4205306787 @default.
• W4328105096 cites W4205494613 @default.
• W4328105096 cites W4291178289 @default.
• W4328105096 doi "https://doi.org/10.1186/s13048-023-01136-y" @default.
• W4328105096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36945010" @default.
• W4328105096 hasPublicationYear "2023" @default.
• W4328105096 type Work @default.
• W4328105096 citedByCount "0" @default.
• W4328105096 crossrefType "journal-article" @default.
• W4328105096 hasAuthorship W4328105096A5002953135 @default.
• W4328105096 hasAuthorship W4328105096A5015824781 @default.
• W4328105096 hasAuthorship W4328105096A5017695859 @default.
• W4328105096 hasAuthorship W4328105096A5026546306 @default.
• W4328105096 hasAuthorship W4328105096A5038117148 @default.
• W4328105096 hasAuthorship W4328105096A5038693765 @default.
• W4328105096 hasAuthorship W4328105096A5039523519 @default.
• W4328105096 hasAuthorship W4328105096A5061494260 @default.
• W4328105096 hasAuthorship W4328105096A5064462401 @default.
• W4328105096 hasAuthorship W4328105096A5074592118 @default.
• W4328105096 hasBestOaLocation W43281050961 @default.
• W4328105096 hasConcept C126322002 @default.
• W4328105096 hasConcept C134018914 @default.
• W4328105096 hasConcept C142724271 @default.
• W4328105096 hasConcept C17172800 @default.
• W4328105096 hasConcept C198826908 @default.
• W4328105096 hasConcept C2776914184 @default.
• W4328105096 hasConcept C2777209026 @default.
• W4328105096 hasConcept C2911091166 @default.
• W4328105096 hasConcept C2911206770 @default.
• W4328105096 hasConcept C71924100 @default.
• W4328105096 hasConceptScore W4328105096C126322002 @default.
• W4328105096 hasConceptScore W4328105096C134018914 @default.
• W4328105096 hasConceptScore W4328105096C142724271 @default.
• W4328105096 hasConceptScore W4328105096C17172800 @default.
• W4328105096 hasConceptScore W4328105096C198826908 @default.
• W4328105096 hasConceptScore W4328105096C2776914184 @default.
• W4328105096 hasConceptScore W4328105096C2777209026 @default.
• W4328105096 hasConceptScore W4328105096C2911091166 @default.
• W4328105096 hasConceptScore W4328105096C2911206770 @default.
• W4328105096 hasConceptScore W4328105096C71924100 @default.
• W4328105096 hasFunder F4320321001 @default.
• W4328105096 hasIssue "1" @default.
• W4328105096 hasLocation W43281050961 @default.
• W4328105096 hasLocation W43281050962 @default.
• W4328105096 hasLocation W43281050963 @default.
• W4328105096 hasLocation W43281050964 @default.
• W4328105096 hasOpenAccess W4328105096 @default.
• W4328105096 hasPrimaryLocation W43281050961 @default.
• W4328105096 hasRelatedWork W2748952813 @default.
• W4328105096 hasRelatedWork W2775627464 @default.
• W4328105096 hasRelatedWork W3132853059 @default.
• W4328105096 hasRelatedWork W3205681349 @default.
• W4328105096 hasRelatedWork W3208193014 @default.
• W4328105096 hasRelatedWork W4223520974 @default.
• W4328105096 hasRelatedWork W4295538067 @default.
• W4328105096 hasRelatedWork W4297852423 @default.
• W4328105096 hasRelatedWork W4310974111 @default.
• W4328105096 hasRelatedWork W4328105096 @default.
• W4328105096 hasVolume "16" @default.
• W4328105096 isParatext "false" @default.

• next