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- W4328105359 abstract "In many animal species, including humans, males have shorter lifespan and show faster survival aging than females. This differential increase in mortality between sexes could result from the accumulation of deleterious mutations in the mitochondrial genome of males due to the maternal mode of mtDNA inheritance. To date, empirical evidence supporting the existence of this mechanism - called the Mother Curse hypothesis - remains largely limited to a few study cases in humans and Drosophila. In this study, we tested whether the Mother Curse hypothesis accounts for sex differences in lifespan and aging rate across 128 populations of mammals (60 and 68 populations studied in wild and captive conditions, respectively) encompassing 104 species. We found that adult lifespan decreases with increasing mtDNA neutral substitution rate in both sexes in a similar way in the wild - but not in captivity. Moreover, the aging rate marginally increased with neutral substitution rate in males and females in the wild. Overall, these results indicate that the Mother Curse hypothesis is not supported across mammals. We further discuss the implication of these findings for our understanding of the evolution of sex differences in mortality and aging." @default.
- W4328105359 created "2023-03-22" @default.
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- W4328105359 date "2023-06-01" @default.
- W4328105359 modified "2023-09-30" @default.
- W4328105359 title "Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’" @default.
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- W4328105359 doi "https://doi.org/10.1016/j.mad.2023.111799" @default.
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