FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328105372> ?p ?o ?g. }

• W4328105372 endingPage "148336" @default.
• W4328105372 startingPage "148336" @default.
• W4328105372 abstract "Impaired attention is central to the cognitive deficits associated with long-term sequelae for many traumatic brain injury (TBI) survivors. Assessing complex sustained attention post-TBI is clinically-relevant and may provide reliable avenues towards developing therapeutic and rehabilitation targets in both males and females. We hypothesized that rats subjected to a moderate TBI will exhibit attentional deficits seen as reduced accuracy and increased distractibility in an operant 3-choice serial reaction time task (3-CSRT), designed as an analogue of the clinical continuous performance test. Upon reaching baseline of 70% accuracy at the 300 ms cue, adult male and female Sprague-Dawley rats were subjected to a controlled cortical impact (2.8 mm deformation at 4 m/s) or sham injury over the right parietal cortex. After two weeks of recovery, they were retested on the 3-CSRT for ten days. Dependent measures include percent accuracy (overall and for each of the three cue ports), percent omissions, as well as latency to instrumental poke and retrieve reward. Results demonstrate that both males and females displayed reduced percent accuracy and increased omissions when re-tested post-TBI on 3-CSRT compared to Sham rats and to their own pre-insult baseline (p's < 0.05). Performance accuracy was impaired consistently throughout the ten days of post-surgery re-testing, suggesting pronounced and long-lasting dysfunction in sustained attention processes. Deficits were specifically more pronounced when the cue was pseudorandomly presented in the left-side cue port (p < 0.05), mirroring clinical hemispatial neglect. These data demonstrate significant and persistent complex attention impairments in both sexes after TBI, rendering identifying efficient therapies for cognitive recovery as pivotal." @default.
• W4328105372 created "2023-03-22" @default.
• W4328105372 creator A5002521540 @default.
• W4328105372 creator A5003798960 @default.
• W4328105372 creator A5009249666 @default.
• W4328105372 creator A5023514334 @default.
• W4328105372 creator A5027195041 @default.
• W4328105372 creator A5029581621 @default.
• W4328105372 creator A5030951455 @default.
• W4328105372 creator A5044529135 @default.
• W4328105372 creator A5046725375 @default.
• W4328105372 creator A5051547614 @default.
• W4328105372 creator A5055486451 @default.
• W4328105372 creator A5056318885 @default.
• W4328105372 creator A5059854391 @default.
• W4328105372 creator A5059957628 @default.
• W4328105372 creator A5067488420 @default.
• W4328105372 creator A5091244574 @default.
• W4328105372 date "2023-06-01" @default.
• W4328105372 modified "2023-10-15" @default.
• W4328105372 title "Sustained attention performance deficits in the three-choice serial reaction time task in male and female rats after experimental brain trauma" @default.
• W4328105372 cites W1489781825 @default.
• W4328105372 cites W1572490995 @default.
• W4328105372 cites W1945955617 @default.
• W4328105372 cites W1965424617 @default.
• W4328105372 cites W1984577189 @default.
• W4328105372 cites W1992961203 @default.
• W4328105372 cites W2020136118 @default.
• W4328105372 cites W2026755802 @default.
• W4328105372 cites W2028127185 @default.
• W4328105372 cites W2031322248 @default.
• W4328105372 cites W2034223712 @default.
• W4328105372 cites W2046840006 @default.
• W4328105372 cites W2052884866 @default.
• W4328105372 cites W2053063190 @default.
• W4328105372 cites W2062636034 @default.
• W4328105372 cites W2063142082 @default.
• W4328105372 cites W2077301017 @default.
• W4328105372 cites W2084450131 @default.
• W4328105372 cites W2086532544 @default.
• W4328105372 cites W2094502548 @default.
• W4328105372 cites W2112512101 @default.
• W4328105372 cites W2128495941 @default.
• W4328105372 cites W2133425596 @default.
• W4328105372 cites W2133876080 @default.
• W4328105372 cites W2162660365 @default.
• W4328105372 cites W2171934036 @default.
• W4328105372 cites W2172099208 @default.
• W4328105372 cites W2271170698 @default.
• W4328105372 cites W2346960426 @default.
• W4328105372 cites W2408075767 @default.
• W4328105372 cites W2509413750 @default.
• W4328105372 cites W2727155092 @default.
• W4328105372 cites W2799961863 @default.
• W4328105372 cites W2804302988 @default.
• W4328105372 cites W2892345931 @default.
• W4328105372 cites W2914739179 @default.
• W4328105372 cites W2915478013 @default.
• W4328105372 cites W2921096213 @default.
• W4328105372 cites W3111414023 @default.
• W4328105372 cites W3128677789 @default.
• W4328105372 cites W3162055707 @default.
• W4328105372 cites W3177553404 @default.
• W4328105372 cites W3182541146 @default.
• W4328105372 doi "https://doi.org/10.1016/j.brainres.2023.148336" @default.
• W4328105372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36948353" @default.
• W4328105372 hasPublicationYear "2023" @default.
• W4328105372 type Work @default.
• W4328105372 citedByCount "0" @default.
• W4328105372 crossrefType "journal-article" @default.
• W4328105372 hasAuthorship W4328105372A5002521540 @default.
• W4328105372 hasAuthorship W4328105372A5003798960 @default.
• W4328105372 hasAuthorship W4328105372A5009249666 @default.
• W4328105372 hasAuthorship W4328105372A5023514334 @default.
• W4328105372 hasAuthorship W4328105372A5027195041 @default.
• W4328105372 hasAuthorship W4328105372A5029581621 @default.
• W4328105372 hasAuthorship W4328105372A5030951455 @default.
• W4328105372 hasAuthorship W4328105372A5044529135 @default.
• W4328105372 hasAuthorship W4328105372A5046725375 @default.
• W4328105372 hasAuthorship W4328105372A5051547614 @default.
• W4328105372 hasAuthorship W4328105372A5055486451 @default.
• W4328105372 hasAuthorship W4328105372A5056318885 @default.
• W4328105372 hasAuthorship W4328105372A5059854391 @default.
• W4328105372 hasAuthorship W4328105372A5059957628 @default.
• W4328105372 hasAuthorship W4328105372A5067488420 @default.
• W4328105372 hasAuthorship W4328105372A5091244574 @default.
• W4328105372 hasConcept C118552586 @default.
• W4328105372 hasConcept C142724271 @default.
• W4328105372 hasConcept C15744967 @default.
• W4328105372 hasConcept C169760540 @default.
• W4328105372 hasConcept C169900460 @default.
• W4328105372 hasConcept C204787440 @default.
• W4328105372 hasConcept C2775961468 @default.
• W4328105372 hasConcept C2781017439 @default.
• W4328105372 hasConcept C2781114239 @default.
• W4328105372 hasConcept C2910073837 @default.
• W4328105372 hasConcept C548259974 @default.
• W4328105372 hasConcept C71924100 @default.

• next