Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328105763> ?p ?o ?g. }
- W4328105763 endingPage "110634" @default.
- W4328105763 startingPage "110634" @default.
- W4328105763 abstract "We explored the predictive utility of baseline neutrophil/lymphocyte ratio (NLR), which reflects a systemic inflammatory tone, in kidney impairment in type 2 diabetes mellitus (T2DM); and investigated the effect of extracellular water/total body water (ECW/TBW) ratio on the relationship.This longitudinal study included 1,224 T2DM adults recruited from a single centre. Cox regression analyses examined the association between NLR and progressive kidney function decline or albuminuria progression. Improvements in risk discrimination were assessed using Harrell's concordance-statistics. The mediatory role of ECW/TBW ratio estimated by bioelectrical impedance was evaluated.Higher baseline NLR levels were observed in cases with kidney function decline or albuminuria progression over a median 2-year follow-up. NLR independently predicted progressive kidney function decline (hazard ratio:1.39, 95% CI:1.21-1.60, P < 0.001) or albuminuria progression (hazard ratio:1.34, 95% CI:1.08-1.68, P = 0.009). Addition of NLR to a base model comprising demographics, T2DM duration, metabolic and renal parameters, and medications significantly improved the risk discrimination of kidney function decline (P = 0.022) but not albuminuria progression. ECW/TBW ratio accounted for 19.7% of the total effect between NLR and kidney function loss.Increased NLR reflecting systemic inflammation is associated with progressive kidney function decline in T2DM, partially explained by dysregulated body fluid balance." @default.
- W4328105763 created "2023-03-22" @default.
- W4328105763 creator A5011330789 @default.
- W4328105763 creator A5036039345 @default.
- W4328105763 creator A5054600137 @default.
- W4328105763 creator A5066365214 @default.
- W4328105763 creator A5080640808 @default.
- W4328105763 creator A5084975197 @default.
- W4328105763 date "2023-05-01" @default.
- W4328105763 modified "2023-10-13" @default.
- W4328105763 title "Association between neutrophil/lymphocyte ratio and kidney impairment in type 2 diabetes mellitus: A role of extracellular water/total body water ratio" @default.
- W4328105763 cites W1975932722 @default.
- W4328105763 cites W1996854381 @default.
- W4328105763 cites W2001307992 @default.
- W4328105763 cites W2018110777 @default.
- W4328105763 cites W2028322600 @default.
- W4328105763 cites W2061817584 @default.
- W4328105763 cites W2112669742 @default.
- W4328105763 cites W2125833000 @default.
- W4328105763 cites W2127680586 @default.
- W4328105763 cites W2133022606 @default.
- W4328105763 cites W2147542332 @default.
- W4328105763 cites W2148140784 @default.
- W4328105763 cites W2155965977 @default.
- W4328105763 cites W2227552016 @default.
- W4328105763 cites W2510931315 @default.
- W4328105763 cites W2517180753 @default.
- W4328105763 cites W2738900433 @default.
- W4328105763 cites W2762816177 @default.
- W4328105763 cites W2790803481 @default.
- W4328105763 cites W2809598073 @default.
- W4328105763 cites W2886959382 @default.
- W4328105763 cites W2897021817 @default.
- W4328105763 cites W2906340657 @default.
- W4328105763 cites W2970412630 @default.
- W4328105763 cites W3012917967 @default.
- W4328105763 cites W3014323041 @default.
- W4328105763 cites W3018358973 @default.
- W4328105763 cites W3021159047 @default.
- W4328105763 cites W3094429645 @default.
- W4328105763 cites W3095172315 @default.
- W4328105763 cites W3153719230 @default.
- W4328105763 cites W3181044742 @default.
- W4328105763 cites W3184682008 @default.
- W4328105763 cites W3212624306 @default.
- W4328105763 cites W4200454061 @default.
- W4328105763 cites W4220947320 @default.
- W4328105763 cites W4225655571 @default.
- W4328105763 cites W4310459840 @default.
- W4328105763 cites W4312178684 @default.
- W4328105763 cites W4313248167 @default.
- W4328105763 cites W4313433467 @default.
- W4328105763 doi "https://doi.org/10.1016/j.diabres.2023.110634" @default.
- W4328105763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36948421" @default.
- W4328105763 hasPublicationYear "2023" @default.
- W4328105763 type Work @default.
- W4328105763 citedByCount "2" @default.
- W4328105763 crossrefType "journal-article" @default.
- W4328105763 hasAuthorship W4328105763A5011330789 @default.
- W4328105763 hasAuthorship W4328105763A5036039345 @default.
- W4328105763 hasAuthorship W4328105763A5054600137 @default.
- W4328105763 hasAuthorship W4328105763A5066365214 @default.
- W4328105763 hasAuthorship W4328105763A5080640808 @default.
- W4328105763 hasAuthorship W4328105763A5084975197 @default.
- W4328105763 hasConcept C126322002 @default.
- W4328105763 hasConcept C134018914 @default.
- W4328105763 hasConcept C159641895 @default.
- W4328105763 hasConcept C207103383 @default.
- W4328105763 hasConcept C2776174234 @default.
- W4328105763 hasConcept C2777761686 @default.
- W4328105763 hasConcept C2778653478 @default.
- W4328105763 hasConcept C2778963024 @default.
- W4328105763 hasConcept C2780091579 @default.
- W4328105763 hasConcept C2780221984 @default.
- W4328105763 hasConcept C2910068830 @default.
- W4328105763 hasConcept C33872192 @default.
- W4328105763 hasConcept C44249647 @default.
- W4328105763 hasConcept C555293320 @default.
- W4328105763 hasConcept C71924100 @default.
- W4328105763 hasConceptScore W4328105763C126322002 @default.
- W4328105763 hasConceptScore W4328105763C134018914 @default.
- W4328105763 hasConceptScore W4328105763C159641895 @default.
- W4328105763 hasConceptScore W4328105763C207103383 @default.
- W4328105763 hasConceptScore W4328105763C2776174234 @default.
- W4328105763 hasConceptScore W4328105763C2777761686 @default.
- W4328105763 hasConceptScore W4328105763C2778653478 @default.
- W4328105763 hasConceptScore W4328105763C2778963024 @default.
- W4328105763 hasConceptScore W4328105763C2780091579 @default.
- W4328105763 hasConceptScore W4328105763C2780221984 @default.
- W4328105763 hasConceptScore W4328105763C2910068830 @default.
- W4328105763 hasConceptScore W4328105763C33872192 @default.
- W4328105763 hasConceptScore W4328105763C44249647 @default.
- W4328105763 hasConceptScore W4328105763C555293320 @default.
- W4328105763 hasConceptScore W4328105763C71924100 @default.
- W4328105763 hasLocation W43281057631 @default.
- W4328105763 hasLocation W43281057632 @default.
- W4328105763 hasOpenAccess W4328105763 @default.
- W4328105763 hasPrimaryLocation W43281057631 @default.