Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328105784> ?p ?o ?g. }
- W4328105784 endingPage "3973" @default.
- W4328105784 startingPage "3973" @default.
- W4328105784 abstract "Synthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In this study, water extracts from the leaves of Cyclopia genistoides (C. genistoides), commonly known as honeybush (HB), were used to synthesize honeybush gold nanoparticles (HB-AuNPs). The HB water extracts (HBE) served as both reducing and capping agents in the synthesis of HB-AuNPs. The HB-AuNPs were characterized by UV–Vis spectrophotometry, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The cytotoxicity and apoptotic effects of the HBE and HB-AuNPs, alone and in combination with doxorubicin (Dox), were examined against various human cell lines. Spherical-shaped HB-AuNPs with a hydrodynamic diameter range of 63 to 121 nm were produced. The HB-AuNPs conferred selective cytotoxicity against colon (Caco-2), breast (MCF-7), and prostate (PC-3) cancer cells and did not display any cytotoxicity to non-cancerous skin fibroblast (KMST-6) and human embryonic kidney (HEK)-293 cells. Moreover, co-treatment of Caco-2 cells with HB-AuNPs and Dox (at non-toxic concentrations) significantly enhanced the anti-cancer effects of Dox towards the Caco-2 cells. Furthermore, it was demonstrated that HB-AuNPs induced PC-3 cell death through apoptosis. Further studies are warranted to elucidate the mechanisms by which the HB-AuNPs influence cell death when used alone or in combination with drugs, as well as the type of phytochemicals involved in AuNPs synthesis and activity." @default.
- W4328105784 created "2023-03-22" @default.
- W4328105784 creator A5004651450 @default.
- W4328105784 creator A5013075340 @default.
- W4328105784 creator A5040283872 @default.
- W4328105784 creator A5056654888 @default.
- W4328105784 creator A5061975907 @default.
- W4328105784 creator A5064181866 @default.
- W4328105784 creator A5068139778 @default.
- W4328105784 date "2023-03-21" @default.
- W4328105784 modified "2023-10-18" @default.
- W4328105784 title "Anticancer and Drug-Sensitizing Activities of Gold Nanoparticles Synthesized from Cyclopia genistoides (Honeybush) Extracts" @default.
- W4328105784 cites W1971903516 @default.
- W4328105784 cites W1973681903 @default.
- W4328105784 cites W1984092714 @default.
- W4328105784 cites W1997528797 @default.
- W4328105784 cites W2000045071 @default.
- W4328105784 cites W2002470534 @default.
- W4328105784 cites W2012260517 @default.
- W4328105784 cites W2026535241 @default.
- W4328105784 cites W2040144917 @default.
- W4328105784 cites W2044186731 @default.
- W4328105784 cites W2048776397 @default.
- W4328105784 cites W2051170342 @default.
- W4328105784 cites W2081714446 @default.
- W4328105784 cites W2084186494 @default.
- W4328105784 cites W2091786534 @default.
- W4328105784 cites W2097706083 @default.
- W4328105784 cites W2120982778 @default.
- W4328105784 cites W2134304198 @default.
- W4328105784 cites W2139433200 @default.
- W4328105784 cites W2167741612 @default.
- W4328105784 cites W2197190620 @default.
- W4328105784 cites W2264350189 @default.
- W4328105784 cites W2329172048 @default.
- W4328105784 cites W2464210583 @default.
- W4328105784 cites W2529681420 @default.
- W4328105784 cites W2553559538 @default.
- W4328105784 cites W2557449045 @default.
- W4328105784 cites W2608438229 @default.
- W4328105784 cites W2618408906 @default.
- W4328105784 cites W2680362228 @default.
- W4328105784 cites W2727586157 @default.
- W4328105784 cites W2765234970 @default.
- W4328105784 cites W2769986189 @default.
- W4328105784 cites W2886600801 @default.
- W4328105784 cites W2948239944 @default.
- W4328105784 cites W2966238051 @default.
- W4328105784 cites W2988136913 @default.
- W4328105784 cites W2991459932 @default.
- W4328105784 cites W3000302655 @default.
- W4328105784 cites W3088986342 @default.
- W4328105784 cites W3090277600 @default.
- W4328105784 cites W3090370758 @default.
- W4328105784 cites W3096252251 @default.
- W4328105784 cites W3119082786 @default.
- W4328105784 cites W3132995101 @default.
- W4328105784 cites W3200209473 @default.
- W4328105784 cites W4200050209 @default.
- W4328105784 cites W4221022112 @default.
- W4328105784 cites W4283206309 @default.
- W4328105784 cites W4308572918 @default.
- W4328105784 doi "https://doi.org/10.3390/app13063973" @default.
- W4328105784 hasPublicationYear "2023" @default.
- W4328105784 type Work @default.
- W4328105784 citedByCount "1" @default.
- W4328105784 countsByYear W43281057842023 @default.
- W4328105784 crossrefType "journal-article" @default.
- W4328105784 hasAuthorship W4328105784A5004651450 @default.
- W4328105784 hasAuthorship W4328105784A5013075340 @default.
- W4328105784 hasAuthorship W4328105784A5040283872 @default.
- W4328105784 hasAuthorship W4328105784A5056654888 @default.
- W4328105784 hasAuthorship W4328105784A5061975907 @default.
- W4328105784 hasAuthorship W4328105784A5064181866 @default.
- W4328105784 hasAuthorship W4328105784A5068139778 @default.
- W4328105784 hasBestOaLocation W43281057841 @default.
- W4328105784 hasConcept C104819515 @default.
- W4328105784 hasConcept C109316439 @default.
- W4328105784 hasConcept C121608353 @default.
- W4328105784 hasConcept C126322002 @default.
- W4328105784 hasConcept C155672457 @default.
- W4328105784 hasConcept C171250308 @default.
- W4328105784 hasConcept C178790620 @default.
- W4328105784 hasConcept C185592680 @default.
- W4328105784 hasConcept C190283241 @default.
- W4328105784 hasConcept C192562407 @default.
- W4328105784 hasConcept C202751555 @default.
- W4328105784 hasConcept C2776694085 @default.
- W4328105784 hasConcept C2777230088 @default.
- W4328105784 hasConcept C2777366897 @default.
- W4328105784 hasConcept C2779820397 @default.
- W4328105784 hasConcept C2781303535 @default.
- W4328105784 hasConcept C55493867 @default.
- W4328105784 hasConcept C71924100 @default.
- W4328105784 hasConcept C96232424 @default.
- W4328105784 hasConcept C98274493 @default.
- W4328105784 hasConceptScore W4328105784C104819515 @default.
- W4328105784 hasConceptScore W4328105784C109316439 @default.