Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328105814> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4328105814 endingPage "115352" @default.
- W4328105814 startingPage "115352" @default.
- W4328105814 abstract "Anagrelide (ANG) is a widely used drug for the treatment of essential thrombocytosis and myeloproliferative neoplasms. Recently, a new oxidative degradant was identified when the drug product capsule underwent stress testing. Full structural characterization of this previously unidentified degradant was conducted. Preliminary LC-MS analysis indicated the targeted degradant as a mono-oxygenated product of ANG. For the purpose of facile isolation and purification, various forced degradation conditions were screened to enrich the desired degradant, among which, pyridinium chlorochromate (PCC)-treatment effectively afforded a yield of 55 % unknown degradant. Following isolation by prep-HPLC, 1D and 2D NMR studies and HRMS characterization assigned the products as a pair of 5-hydroxy-Anagrelide (5-OH-ANG) enantiomers. A plausible mechanism of formation is proposed." @default.
- W4328105814 created "2023-03-22" @default.
- W4328105814 creator A5010528603 @default.
- W4328105814 creator A5019560977 @default.
- W4328105814 creator A5033699090 @default.
- W4328105814 creator A5049430260 @default.
- W4328105814 creator A5084299251 @default.
- W4328105814 creator A5085234028 @default.
- W4328105814 date "2023-05-01" @default.
- W4328105814 modified "2023-09-28" @default.
- W4328105814 title "Identification and enrichment of a UV-induced degradant of Anagrelide drug substance" @default.
- W4328105814 cites W1900493176 @default.
- W4328105814 cites W1979831105 @default.
- W4328105814 cites W1994395513 @default.
- W4328105814 cites W2000269537 @default.
- W4328105814 cites W2018522840 @default.
- W4328105814 cites W2021978173 @default.
- W4328105814 cites W2056740371 @default.
- W4328105814 cites W2060458113 @default.
- W4328105814 cites W2097496972 @default.
- W4328105814 cites W2133317577 @default.
- W4328105814 cites W2976365784 @default.
- W4328105814 cites W3107196878 @default.
- W4328105814 cites W3201102443 @default.
- W4328105814 doi "https://doi.org/10.1016/j.jpba.2023.115352" @default.
- W4328105814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36989665" @default.
- W4328105814 hasPublicationYear "2023" @default.
- W4328105814 type Work @default.
- W4328105814 citedByCount "0" @default.
- W4328105814 crossrefType "journal-article" @default.
- W4328105814 hasAuthorship W4328105814A5010528603 @default.
- W4328105814 hasAuthorship W4328105814A5019560977 @default.
- W4328105814 hasAuthorship W4328105814A5033699090 @default.
- W4328105814 hasAuthorship W4328105814A5049430260 @default.
- W4328105814 hasAuthorship W4328105814A5084299251 @default.
- W4328105814 hasAuthorship W4328105814A5085234028 @default.
- W4328105814 hasConcept C126322002 @default.
- W4328105814 hasConcept C185592680 @default.
- W4328105814 hasConcept C2780035454 @default.
- W4328105814 hasConcept C2780829020 @default.
- W4328105814 hasConcept C2781057849 @default.
- W4328105814 hasConcept C43617362 @default.
- W4328105814 hasConcept C71240020 @default.
- W4328105814 hasConcept C71924100 @default.
- W4328105814 hasConcept C89560881 @default.
- W4328105814 hasConcept C98274493 @default.
- W4328105814 hasConceptScore W4328105814C126322002 @default.
- W4328105814 hasConceptScore W4328105814C185592680 @default.
- W4328105814 hasConceptScore W4328105814C2780035454 @default.
- W4328105814 hasConceptScore W4328105814C2780829020 @default.
- W4328105814 hasConceptScore W4328105814C2781057849 @default.
- W4328105814 hasConceptScore W4328105814C43617362 @default.
- W4328105814 hasConceptScore W4328105814C71240020 @default.
- W4328105814 hasConceptScore W4328105814C71924100 @default.
- W4328105814 hasConceptScore W4328105814C89560881 @default.
- W4328105814 hasConceptScore W4328105814C98274493 @default.
- W4328105814 hasLocation W43281058141 @default.
- W4328105814 hasLocation W43281058142 @default.
- W4328105814 hasOpenAccess W4328105814 @default.
- W4328105814 hasPrimaryLocation W43281058141 @default.
- W4328105814 hasRelatedWork W1970974546 @default.
- W4328105814 hasRelatedWork W1983544050 @default.
- W4328105814 hasRelatedWork W1996140555 @default.
- W4328105814 hasRelatedWork W2068144347 @default.
- W4328105814 hasRelatedWork W2082518775 @default.
- W4328105814 hasRelatedWork W2125138090 @default.
- W4328105814 hasRelatedWork W2141845144 @default.
- W4328105814 hasRelatedWork W2794783788 @default.
- W4328105814 hasRelatedWork W3024440267 @default.
- W4328105814 hasRelatedWork W4213271907 @default.
- W4328105814 hasVolume "229" @default.
- W4328105814 isParatext "false" @default.
- W4328105814 isRetracted "false" @default.
- W4328105814 workType "article" @default.