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• W4328108240 abstract "Primary percutaneous coronary intervention (pPCI) performed for STEMI may be complicated by the no-reflow phenomenon.A super-selective intracoronary injection of saline solution through a thrombus aspiration catheter (SALINE technique), was investigated for the treatment of no-reflow as compared with the standard care of therapy (SCT).Among the 1471 patients with STEMI undergoing pPCI between May 2015 and June 2020, 168 patients developed no-reflow. Primary endpoints were the incidence of ST-segment resolution (STR) ≥ 70% at 90 min after PCI and the rate of flow restoration (TIMI flow grade 3 with an MBG > 1). The secondary endpoint was the incidence of major adverse cardiac and cerebrovascular events at 3 years follow-up.After propensity score matching analysis, patients treated with SALINE showed STR ≥ 70% in twelve out of the sixteen patients (75.0%), compared to only three patients out of the sixteen in the SCT control group (19.0%), (p < 0.004). SALINE was associated with a higher probability of final TIMI flow grade 3 with an MBG > 1, as shown in fourteen out of sixteen patients (87.5%), as compared to only seven out of sixteen patients in the SCT group (43.8%), (p < 0.03). MACCE at 3 years follow-up occurred in only one patient (6.3%) in the SALINE group, as compared to eight patients (50%) in the SCT group (p = 0.047).The SALINE technique showed to be a safe and effective strategy to reduce no-reflow in STEMI patients as assessed by significant STR, improvement of TIMI flow grade, and better 3-year outcomes." @default.
• W4328108240 created "2023-03-22" @default.
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• W4328108240 date "2023-03-21" @default.
• W4328108240 modified "2023-09-25" @default.
• W4328108240 title "The SALINE Technique for the Treatment of the No-Reflow Phenomenon during Percutaneous Coronary Intervention in STEMI" @default.
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• W4328108240 doi "https://doi.org/10.3390/jcm12062405" @default.
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