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- W4328108570 abstract "Circulating extracellular vesicles (EVs) are proposed to participate in enhancing pathways of recovery after stroke through paracrine signaling. To verify this hypothesis in a proof-of-concept study, blood-derived allogenic EVs from rats and xenogenic EVs from humans who experienced spontaneous good recovery after an intracerebral hemorrhage (ICH) were administered intravenously to rats at 24 h after a subcortical ICH. At 28 days, both treatments improved the motor function assessment scales score, showed greater fiber preservation in the perilesional zone (diffusion tensor-fractional anisotropy MRI), increased immunofluorescence markers of myelin (MOG), and decreased astrocyte markers (GFAP) compared with controls. Comparison of the protein cargo of circulating EVs at 28 days from animals with good vs. poor recovery showed down-expression of immune system activation pathways (CO4, KLKB1, PROC, FA9, and C1QA) and of restorative processes such as axon guidance (RAC1), myelination (MBP), and synaptic vesicle trafficking (SYN1), which is in line with better tissue preservation. Up-expression of PCSK9 (neuron differentiation) in xenogenic EVs-treated animals suggests enhancement of repair pathways. In conclusion, the administration of blood-derived EVs improved recovery after ICH. These findings open a new and promising opportunity for further development of restorative therapies to improve the outcomes after an ICH." @default.
- W4328108570 created "2023-03-22" @default.
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- W4328108570 date "2023-06-01" @default.
- W4328108570 modified "2023-10-17" @default.
- W4328108570 title "Circulating extracellular vesicles promote recovery in a preclinical model of intracerebral hemorrhage" @default.
- W4328108570 cites W1034531949 @default.
- W4328108570 cites W1538522759 @default.
- W4328108570 cites W1894141023 @default.
- W4328108570 cites W1911185606 @default.
- W4328108570 cites W1965637915 @default.
- W4328108570 cites W1968947739 @default.
- W4328108570 cites W1970488935 @default.
- W4328108570 cites W1980170858 @default.
- W4328108570 cites W1996660321 @default.
- W4328108570 cites W2005795053 @default.
- W4328108570 cites W2013774084 @default.
- W4328108570 cites W2024221937 @default.
- W4328108570 cites W2035018608 @default.
- W4328108570 cites W2035084050 @default.
- W4328108570 cites W2049683137 @default.
- W4328108570 cites W2054135378 @default.
- W4328108570 cites W2055424631 @default.
- W4328108570 cites W2063528788 @default.
- W4328108570 cites W2069746005 @default.
- W4328108570 cites W2078669364 @default.
- W4328108570 cites W2083198066 @default.
- W4328108570 cites W2088216089 @default.
- W4328108570 cites W2094711438 @default.
- W4328108570 cites W2135285893 @default.
- W4328108570 cites W2142137941 @default.
- W4328108570 cites W2148658155 @default.
- W4328108570 cites W2152546971 @default.
- W4328108570 cites W2166469175 @default.
- W4328108570 cites W2177788064 @default.
- W4328108570 cites W2520597008 @default.
- W4328108570 cites W2527897220 @default.
- W4328108570 cites W2534361057 @default.
- W4328108570 cites W2565176752 @default.
- W4328108570 cites W2586399067 @default.
- W4328108570 cites W2595546888 @default.
- W4328108570 cites W2753219581 @default.
- W4328108570 cites W2753733426 @default.
- W4328108570 cites W2791714815 @default.
- W4328108570 cites W2795523469 @default.
- W4328108570 cites W2883100197 @default.
- W4328108570 cites W2885177434 @default.
- W4328108570 cites W2891595683 @default.
- W4328108570 cites W2904009457 @default.
- W4328108570 cites W2912674186 @default.
- W4328108570 cites W2921112006 @default.
- W4328108570 cites W2945162057 @default.
- W4328108570 cites W2946298500 @default.
- W4328108570 cites W2949351365 @default.
- W4328108570 cites W2971541720 @default.
- W4328108570 cites W2982704603 @default.
- W4328108570 cites W2991481938 @default.
- W4328108570 cites W2998766901 @default.
- W4328108570 cites W3001058124 @default.
- W4328108570 cites W3008926298 @default.
- W4328108570 cites W3011116178 @default.
- W4328108570 cites W3012749358 @default.
- W4328108570 cites W3025429771 @default.
- W4328108570 cites W3032530697 @default.
- W4328108570 cites W3036596408 @default.
- W4328108570 cites W3039992369 @default.
- W4328108570 cites W3081919405 @default.
- W4328108570 cites W3097059144 @default.
- W4328108570 cites W3106177795 @default.
- W4328108570 cites W3112376646 @default.
- W4328108570 cites W3129846610 @default.
- W4328108570 cites W3134719649 @default.
- W4328108570 cites W3160541559 @default.
- W4328108570 cites W3169960216 @default.
- W4328108570 cites W3173559534 @default.
- W4328108570 cites W3184374917 @default.
- W4328108570 cites W3199937649 @default.
- W4328108570 cites W3208691473 @default.
- W4328108570 cites W3215977515 @default.
- W4328108570 cites W4317425546 @default.
- W4328108570 cites W82712039 @default.