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- W4328109482 abstract "The detection of microRNA is widely used in the early diagnosis of diseases such as cancer and acute kidney injury. In this work, we successfully constructed a label-free ultrasensitive biosensor for the instant detection of miRNA-21. The MXene-reduced graphene oxide (rGO)-Au was synthesized as electrode materials to immobilize DNA probes and MXene-AuPd was used as signal amplification materials. The highly sensitive biosensor had a wide range of linearity from 1 fM to 1 nM, and the limit of detection of as-fabricated biosensor was lower as 0.42 fM under optimized conditions. The biosensor also showed high specificity, outstanding stability and desirable reproducibility, which could also realize the accurate detection of miRNA-21 in real urine samples of both mouse and human with high sensitivity. The label-free electrochemical biosensor based on MXene nanocomposites is a promising candidate for potential applications on the early diagnosis of cancers and acute kidney injury." @default.
- W4328109482 created "2023-03-22" @default.
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- W4328109482 date "2023-07-01" @default.
- W4328109482 modified "2023-10-18" @default.
- W4328109482 title "A label-free ultrasensitive microRNA-21 electrochemical biosensor based on MXene (Ti3C2)-reduced graphene oxide-Au nanocomposites" @default.
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- W4328109482 doi "https://doi.org/10.1016/j.microc.2023.108656" @default.
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