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• W4328110979 abstract "Abstract Background: Intervertebral disc degeneration (IDD) and vertebral endplate Modic changes (MCs) are common lumbar degenerative phenotypes related to low back pain (LBP). Dyslipidemia has been linked to LBP but its associations with IDD and MCs have not been fully elucidated. The present study aimed to address the possible link between dyslipidemia, IDD and MCs in the Chinese population. Methods: 1035 citizens were enrolled in the study. The levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were collected. IDD was evaluated based on the Pfirrmann grading system and subjects with an average grade ≥3 were defined as having degeneration. MCs were classified into typical types 1, 2 and 3. Covariables, including age, sex, BMI and fasting plasma glucose, were included for the adjustment of the logistic analyses. Results: The degeneration group included 446 subjects while the nondegeneration group included 589 subjects. The degeneration group had significant higher levels of TC and LDL-C ( p <0.001) whereas TG and HDL-C were not significant different between the two groups. TC and LDL-C concentrations were significantly positively correlated with average IDD grades ( p <0.001). Multivariate logistic regression revealed that high TC (≥6.2 mmol/L, adjusted OR=1.775, 95% CI=1.209-2.606) and high LDL-C (≥4.1 mmol/L, adjusted OR=1.818, 95% CI=1.123-2.943) were independent risk factors for IDD. Type 1 MC presented in 84 (8.12%) subjects, type 2 MC presented in 244 (23.57%) subjects, type 3 MC presented in 27 (2.61%) subjects and no MC was observed in the remaining 680 (65.70%) subjects. The type 2 MC group demonstrated a higher level of TC, but the association between serum lipids and MCs could not be confirmed in further multivariate logistic regression. Conclusions: High TC (≥6.2 mmol/L) and LDL-C (≥4.1 mmol/L) concentrations were recognized as independent risk factors for IDD for citizens in China. However, the epidemiological association between dyslipidemia and MCs could not be determined. The biomolecular effect of excess serum cholesterol may play a vital role in the development of IDD. Hypolipidemic treatment, especially when targeting cholesterol, may provide new opportunities in the management of lumbar disc degenerative diseases." @default.
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• W4328110979 date "2023-03-21" @default.
• W4328110979 modified "2023-09-30" @default.
• W4328110979 title "The impact of dyslipidemia on lumbar intervertebral disc degeneration and vertebral endplate modic changes: a cross-sectional study of 1035 citizens in China" @default.
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• W4328110979 doi "https://doi.org/10.21203/rs.3.rs-2662348/v1" @default.
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