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- W4328111571 abstract "Tapentadol is an analgesic compound that acts centrally to attenuate pain. Previous studies have shown that tapentadol has dual mechanisms of action as a mu-opioid receptor agonist and noradrenaline re-uptake inhibition. Therefore, tapentadol provides a great advantage over classic opioids in pain management from nociceptive to neuropathic. Cumulative evidence from in vitro data suggests that tapentadol effect of norepinephrine re-uptake could be a new target that overcomes other classic opioids in chronic neuropathic pain. Compared to tramadol and other opioids, tapentadol is associated with fewer adverse effects than tramadol. Tapentadol is a new alternative to treat acute, chronic, and neuropathic pain. Thus, this review article was focused on understanding the studies that led to the development of tapentadol as a novel analgesic drug and its advantages over conventional opioids. Thus, tapentadol is a good alternative with fewer adverse effects and is available for human use." @default.
- W4328111571 created "2023-03-22" @default.
- W4328111571 creator A5002549713 @default.
- W4328111571 date "2023-03-01" @default.
- W4328111571 modified "2023-09-30" @default.
- W4328111571 title "Tapentadol: A Review of Experimental Pharmacology Studies, Clinical Trials, and Recent Findings" @default.
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- W4328111571 doi "https://doi.org/10.2147/dddt.s402362" @default.
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