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- W4328111830 abstract "All cells employ signal transduction pathways to respond to physiologically relevant extracellular cytokines, stressors, nutrient levels, hormones, morphogens, and other stimuli that vary in concentration and rate in healthy and diseased states. A central unsolved fundamental question in cell signaling is whether and how cells sense and integrate information conveyed by changes in the rate of extracellular stimuli concentrations, in addition to the absolute difference in concentration. We propose that different environmental changes over time influence cell behavior in addition to different signaling molecules or different genetic backgrounds. However, most current biomedical research focuses on acute environmental changes and does not consider how cells respond to environments that change slowly over time. As an example of such environmental change, we review cell sensitivity to environmental rate changes, including the novel mechanism of rate threshold. A rate threshold is defined as a threshold in the rate of change in the environment in which a rate value below the threshold does not activate signaling and a rate value above the threshold leads to signal activation. We reviewed p38/Hog1 osmotic stress signaling in yeast, chemotaxis and stress response in bacteria, cyclic adenosine monophosphate signaling in Amoebae, growth factors signaling in mammalian cells, morphogen dynamics during development, temporal dynamics of glucose and insulin signaling, and spatio-temproral stressors in the kidney. These reviewed examples from the literature indicate that rate thresholds are widespread and an underappreciated fundamental property of cell signaling. Finally, by studying cells in non-linear environments, we outline future directions to understand cell physiology better in normal and pathophysiological conditions." @default.
- W4328111830 created "2023-03-22" @default.
- W4328111830 creator A5040545108 @default.
- W4328111830 creator A5083807136 @default.
- W4328111830 date "2023-03-21" @default.
- W4328111830 modified "2023-09-25" @default.
- W4328111830 title "Rate thresholds in cell signaling have functional and phenotypic consequences in non-linear time-dependent environments" @default.
- W4328111830 cites W1838792009 @default.
- W4328111830 cites W1898443428 @default.
- W4328111830 cites W1965435094 @default.
- W4328111830 cites W1972946410 @default.
- W4328111830 cites W1974475129 @default.
- W4328111830 cites W1975444080 @default.
- W4328111830 cites W1977885600 @default.
- W4328111830 cites W1979892077 @default.
- W4328111830 cites W1984429906 @default.
- W4328111830 cites W1987315263 @default.
- W4328111830 cites W1988604934 @default.
- W4328111830 cites W1992717202 @default.
- W4328111830 cites W1993902553 @default.
- W4328111830 cites W2000329555 @default.
- W4328111830 cites W2003155571 @default.
- W4328111830 cites W2005693445 @default.
- W4328111830 cites W2008794157 @default.
- W4328111830 cites W2009651971 @default.
- W4328111830 cites W2011033752 @default.
- W4328111830 cites W2023788610 @default.
- W4328111830 cites W2026519680 @default.
- W4328111830 cites W2027529467 @default.
- W4328111830 cites W2029086616 @default.
- W4328111830 cites W2029454495 @default.
- W4328111830 cites W2031093127 @default.
- W4328111830 cites W2050936151 @default.
- W4328111830 cites W2067443877 @default.
- W4328111830 cites W2071920845 @default.
- W4328111830 cites W2072511250 @default.
- W4328111830 cites W2072676547 @default.
- W4328111830 cites W2078902399 @default.
- W4328111830 cites W2079588007 @default.
- W4328111830 cites W2079696996 @default.
- W4328111830 cites W2083249373 @default.
- W4328111830 cites W2084952038 @default.
- W4328111830 cites W2087672211 @default.
- W4328111830 cites W2090013807 @default.
- W4328111830 cites W2096510468 @default.
- W4328111830 cites W2105538438 @default.
- W4328111830 cites W2108470769 @default.
- W4328111830 cites W2109309568 @default.
- W4328111830 cites W2109626757 @default.
- W4328111830 cites W2112225255 @default.
- W4328111830 cites W2119184935 @default.
- W4328111830 cites W2120170134 @default.
- W4328111830 cites W2123973944 @default.
- W4328111830 cites W2124518386 @default.
- W4328111830 cites W2128881595 @default.
- W4328111830 cites W2131591423 @default.
- W4328111830 cites W2132083187 @default.
- W4328111830 cites W2132507158 @default.
- W4328111830 cites W2132926156 @default.
- W4328111830 cites W2133403209 @default.
- W4328111830 cites W2134803212 @default.
- W4328111830 cites W2135808501 @default.
- W4328111830 cites W2137567526 @default.
- W4328111830 cites W2137683543 @default.
- W4328111830 cites W2140443734 @default.
- W4328111830 cites W2141879066 @default.
- W4328111830 cites W2142072523 @default.
- W4328111830 cites W2143282379 @default.
- W4328111830 cites W2145871402 @default.
- W4328111830 cites W2147387884 @default.
- W4328111830 cites W2148121753 @default.
- W4328111830 cites W2149182211 @default.
- W4328111830 cites W2150317682 @default.
- W4328111830 cites W2151490359 @default.
- W4328111830 cites W2152667161 @default.
- W4328111830 cites W2153624566 @default.
- W4328111830 cites W2164578658 @default.
- W4328111830 cites W2167468292 @default.
- W4328111830 cites W2171109336 @default.
- W4328111830 cites W2175307482 @default.
- W4328111830 cites W2556346726 @default.
- W4328111830 cites W2601584115 @default.
- W4328111830 cites W2607064799 @default.
- W4328111830 cites W2615936294 @default.
- W4328111830 cites W2750346291 @default.
- W4328111830 cites W2751928832 @default.
- W4328111830 cites W2769585090 @default.
- W4328111830 cites W2774136235 @default.
- W4328111830 cites W2777094855 @default.
- W4328111830 cites W2795791343 @default.
- W4328111830 cites W2810748300 @default.
- W4328111830 cites W2888162061 @default.
- W4328111830 cites W2909412269 @default.
- W4328111830 cites W2919475439 @default.
- W4328111830 cites W2953942915 @default.
- W4328111830 cites W2954783208 @default.
- W4328111830 cites W2958825963 @default.
- W4328111830 cites W2966992934 @default.
- W4328111830 cites W2975589949 @default.
- W4328111830 cites W3013637434 @default.