Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328112143> ?p ?o ?g. }
- W4328112143 endingPage "105499" @default.
- W4328112143 startingPage "105499" @default.
- W4328112143 abstract "Apigenin-7-O-glucoside (AG), a flavonoid glycoside, has been shown in vitro anti-inflammatory activities. To date, the mechanism of AG against colitis has not been reported. In this study, we investigated the role of AG in relieving colitis and explored its potential mechanisms in dextran sulfate sodium (DSS)-induced colitis mice. The results indicated oral administration of AG increased colon length and improved colonic histopathology. Besides, it dramatically restored the colonic expression of pro-inflammatory and anti-inflammatory mediators, as well as enhanced the expression of intestinal barrier markers such as ZO-1, occludin, claudin-1, and claudin-3. The mitogen-activated protein kinases (MAPKs) including ERK, JNK, and p38 were significantly inhibited. Moreover, 16S rDNA sequencing revealed that AG improved the abundance of Akkermansia, and reduced that of Bacteroides and Desulfovibrio. Taken together, AG supplementation relieved DSS-induced colitis by protecting the intestinal barrier, inhibiting the MAPK pathway, and modulating gut microbiota, which indicated that AG may be a good candidate therapeutic compound for sustaining gut health to lower the risk of colitis." @default.
- W4328112143 created "2023-03-22" @default.
- W4328112143 creator A5004086293 @default.
- W4328112143 creator A5006753025 @default.
- W4328112143 creator A5007613197 @default.
- W4328112143 creator A5033456280 @default.
- W4328112143 creator A5040444564 @default.
- W4328112143 creator A5041286681 @default.
- W4328112143 creator A5042532963 @default.
- W4328112143 creator A5071794451 @default.
- W4328112143 creator A5074672866 @default.
- W4328112143 creator A5076699095 @default.
- W4328112143 creator A5087228040 @default.
- W4328112143 date "2023-05-01" @default.
- W4328112143 modified "2023-10-15" @default.
- W4328112143 title "Apigenin-7-O-glucoside alleviates DSS-induced colitis by improving intestinal barrier function and modulating gut microbiota" @default.
- W4328112143 cites W132429335 @default.
- W4328112143 cites W1647551795 @default.
- W4328112143 cites W1964030232 @default.
- W4328112143 cites W1986079650 @default.
- W4328112143 cites W1992591741 @default.
- W4328112143 cites W2001106467 @default.
- W4328112143 cites W2004608617 @default.
- W4328112143 cites W2007797983 @default.
- W4328112143 cites W2019610958 @default.
- W4328112143 cites W2020978031 @default.
- W4328112143 cites W2028057905 @default.
- W4328112143 cites W2032374729 @default.
- W4328112143 cites W2038984140 @default.
- W4328112143 cites W2042655884 @default.
- W4328112143 cites W2047208232 @default.
- W4328112143 cites W2067987668 @default.
- W4328112143 cites W2115523055 @default.
- W4328112143 cites W2122292170 @default.
- W4328112143 cites W2134624067 @default.
- W4328112143 cites W2136131703 @default.
- W4328112143 cites W2143671472 @default.
- W4328112143 cites W2205526079 @default.
- W4328112143 cites W2254366662 @default.
- W4328112143 cites W2291694997 @default.
- W4328112143 cites W2297994856 @default.
- W4328112143 cites W2525862421 @default.
- W4328112143 cites W2555211960 @default.
- W4328112143 cites W2559267012 @default.
- W4328112143 cites W2563599153 @default.
- W4328112143 cites W2596770143 @default.
- W4328112143 cites W2597544336 @default.
- W4328112143 cites W2619505655 @default.
- W4328112143 cites W2733471197 @default.
- W4328112143 cites W2734970077 @default.
- W4328112143 cites W2741483719 @default.
- W4328112143 cites W2758183934 @default.
- W4328112143 cites W2766754487 @default.
- W4328112143 cites W2789850489 @default.
- W4328112143 cites W2886377967 @default.
- W4328112143 cites W2897998041 @default.
- W4328112143 cites W2902982379 @default.
- W4328112143 cites W2951971718 @default.
- W4328112143 cites W2955964445 @default.
- W4328112143 cites W2977901918 @default.
- W4328112143 cites W2982809154 @default.
- W4328112143 cites W3001780488 @default.
- W4328112143 cites W3009116562 @default.
- W4328112143 cites W3012095940 @default.
- W4328112143 cites W3012409130 @default.
- W4328112143 cites W3031327141 @default.
- W4328112143 cites W3033806493 @default.
- W4328112143 cites W3045601650 @default.
- W4328112143 cites W3080848218 @default.
- W4328112143 cites W3096593806 @default.
- W4328112143 cites W3096867809 @default.
- W4328112143 cites W3097604612 @default.
- W4328112143 cites W3103273725 @default.
- W4328112143 cites W3112596511 @default.
- W4328112143 cites W3123599467 @default.
- W4328112143 cites W3159987011 @default.
- W4328112143 cites W4200430857 @default.
- W4328112143 cites W4230553904 @default.
- W4328112143 doi "https://doi.org/10.1016/j.jff.2023.105499" @default.
- W4328112143 hasPublicationYear "2023" @default.
- W4328112143 type Work @default.
- W4328112143 citedByCount "2" @default.
- W4328112143 countsByYear W43281121432023 @default.
- W4328112143 crossrefType "journal-article" @default.
- W4328112143 hasAuthorship W4328112143A5004086293 @default.
- W4328112143 hasAuthorship W4328112143A5006753025 @default.
- W4328112143 hasAuthorship W4328112143A5007613197 @default.
- W4328112143 hasAuthorship W4328112143A5033456280 @default.
- W4328112143 hasAuthorship W4328112143A5040444564 @default.
- W4328112143 hasAuthorship W4328112143A5041286681 @default.
- W4328112143 hasAuthorship W4328112143A5042532963 @default.
- W4328112143 hasAuthorship W4328112143A5071794451 @default.
- W4328112143 hasAuthorship W4328112143A5074672866 @default.
- W4328112143 hasAuthorship W4328112143A5076699095 @default.
- W4328112143 hasAuthorship W4328112143A5087228040 @default.
- W4328112143 hasBestOaLocation W43281121431 @default.
- W4328112143 hasConcept C100544194 @default.
- W4328112143 hasConcept C177779419 @default.