FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328112736> ?p ?o ?g. }

• W4328112736 abstract "Introduction Cancer of the head and neck is one of the most common cancers in India. Radiotherapy (RT) plays a vital role in the management of head and neck cancer both as a curative and adjuvant modality. Xerostomia is the most common acute and late toxicity. Therefore, this study aimed to analyze radiation-induced xerostomia and the quality of life of patients treated with intensity-modulated radiotherapy (IMRT) and three-dimensional (3D) conformal radiotherapy (3DCRT). Objectives We aim to evaluate radiation-induced acute xerostomia both subjectively and objectively at three-month and one-year post-radiotherapy follow-up period in patients who received radiotherapy in conformal technique (IMRT) to the head and neck region and compare it with those who received the 3DCRT technique. We also aim to assess the recovery of salivary flow in the third month post-radiotherapy by measuring the parotid scintigraphy excretion fraction. Materials and methods Forty patients with head and neck squamous cell carcinoma (SCC) were randomly assigned to the IMRT and 3DCRT arms. Xerostomia during radiation and at three-month and one-year post-radiotherapy follow-up was assessed subjectively using the xerostomia-related quality of life (XeQOL) questionnaire and objectively by measuring the salivary flow rate and parotid scintigraphy. Results The result is analyzed using an independent t-test, Mann-Whitney U test, and Fisher’s exact test. The analysis showed that patients treated with radiation by IMRT showed better XeQOL scores (43.40±2.326 in IMRT and 52.10±2.573 in 3DCRT, p<0.001) and Eating Assessment Tool-10 (EAT-10) score (27.65±2.796 in IMRT and 33.80±1.936 in 3DCRT, p<0.001) compared to those treated with 3DCRT. Analysis of the excretion fraction (EF%) of parotid scintigraphy depicted improvement in EF% for both right and left parotids in the IMRT arm with statistical significance (for right parotid, 25.22±12.98 in IMRT and 19.60±10.17 in 3DCRT, p=0.136, and for left parotid, 28.03±12.51 in IMRT and 15.35±11.49 in 3DCRT, p=0.0019). The mean rate of flow (ROF) of saliva showed a declining trend during the end of radiotherapy treatment compared to baseline, but the mean ROF of saliva was better in IMRT compared to 3DCRT, and the difference was statistically significant. The ROF of saliva starts improving during the one-year post-radiotherapy follow-up period. Pearson’s chi-square test was used to analyze the correlation between mean parotid dose with EF% of parotid scintigraphy, and it showed a negative correlation, which is statistically significant for both 3DCRT and IMRT arms. Conclusion Xerostomia can be reduced by precision radiotherapies such as the parotid-sparing IMRT technique in head and neck cancer patients, hence improving the quality of life." @default.
• W4328112736 created "2023-03-22" @default.
• W4328112736 creator A5031624357 @default.
• W4328112736 creator A5033416703 @default.
• W4328112736 creator A5039624220 @default.
• W4328112736 creator A5047748797 @default.
• W4328112736 creator A5060328602 @default.
• W4328112736 creator A5072277645 @default.
• W4328112736 creator A5086197472 @default.
• W4328112736 date "2023-03-20" @default.
• W4328112736 modified "2023-10-01" @default.
• W4328112736 title "A Prospective Cohort Study Analyzing Radiation-Induced Xerostomia and Quality of Life of Head and Neck Cancer Patients Treated With Intensity-Modulated Radiotherapy and 3D Conformal Radiotherapy Techniques at a Tertiary Cancer Center in Eastern India" @default.
• W4328112736 cites W1559873725 @default.
• W4328112736 cites W1854220427 @default.
• W4328112736 cites W1926503027 @default.
• W4328112736 cites W1938654188 @default.
• W4328112736 cites W1973210445 @default.
• W4328112736 cites W1974833358 @default.
• W4328112736 cites W1982428773 @default.
• W4328112736 cites W1996006776 @default.
• W4328112736 cites W2005574374 @default.
• W4328112736 cites W2014289605 @default.
• W4328112736 cites W2047820042 @default.
• W4328112736 cites W2070982653 @default.
• W4328112736 cites W2074677114 @default.
• W4328112736 cites W2077228610 @default.
• W4328112736 cites W2101568797 @default.
• W4328112736 cites W2113092282 @default.
• W4328112736 cites W2127048767 @default.
• W4328112736 cites W2137335664 @default.
• W4328112736 cites W2138244973 @default.
• W4328112736 cites W2140110477 @default.
• W4328112736 cites W2154757451 @default.
• W4328112736 cites W2168634616 @default.
• W4328112736 cites W2655326870 @default.
• W4328112736 cites W2776869159 @default.
• W4328112736 cites W2826435500 @default.
• W4328112736 cites W3087748728 @default.
• W4328112736 doi "https://doi.org/10.7759/cureus.36442" @default.
• W4328112736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37090370" @default.
• W4328112736 hasPublicationYear "2023" @default.
• W4328112736 type Work @default.
• W4328112736 citedByCount "0" @default.
• W4328112736 crossrefType "journal-article" @default.
• W4328112736 hasAuthorship W4328112736A5031624357 @default.
• W4328112736 hasAuthorship W4328112736A5033416703 @default.
• W4328112736 hasAuthorship W4328112736A5039624220 @default.
• W4328112736 hasAuthorship W4328112736A5047748797 @default.
• W4328112736 hasAuthorship W4328112736A5060328602 @default.
• W4328112736 hasAuthorship W4328112736A5072277645 @default.
• W4328112736 hasAuthorship W4328112736A5086197472 @default.
• W4328112736 hasBestOaLocation W43281127361 @default.
• W4328112736 hasConcept C121608353 @default.
• W4328112736 hasConcept C126322002 @default.
• W4328112736 hasConcept C126838900 @default.
• W4328112736 hasConcept C141071460 @default.
• W4328112736 hasConcept C159110408 @default.
• W4328112736 hasConcept C188816634 @default.
• W4328112736 hasConcept C2776530083 @default.
• W4328112736 hasConcept C2776833033 @default.
• W4328112736 hasConcept C2779951463 @default.
• W4328112736 hasConcept C2989005 @default.
• W4328112736 hasConcept C509974204 @default.
• W4328112736 hasConcept C71924100 @default.
• W4328112736 hasConceptScore W4328112736C121608353 @default.
• W4328112736 hasConceptScore W4328112736C126322002 @default.
• W4328112736 hasConceptScore W4328112736C126838900 @default.
• W4328112736 hasConceptScore W4328112736C141071460 @default.
• W4328112736 hasConceptScore W4328112736C159110408 @default.
• W4328112736 hasConceptScore W4328112736C188816634 @default.
• W4328112736 hasConceptScore W4328112736C2776530083 @default.
• W4328112736 hasConceptScore W4328112736C2776833033 @default.
• W4328112736 hasConceptScore W4328112736C2779951463 @default.
• W4328112736 hasConceptScore W4328112736C2989005 @default.
• W4328112736 hasConceptScore W4328112736C509974204 @default.
• W4328112736 hasConceptScore W4328112736C71924100 @default.
• W4328112736 hasLocation W43281127361 @default.
• W4328112736 hasLocation W43281127362 @default.
• W4328112736 hasLocation W43281127363 @default.
• W4328112736 hasOpenAccess W4328112736 @default.
• W4328112736 hasPrimaryLocation W43281127361 @default.
• W4328112736 hasRelatedWork W1938654188 @default.
• W4328112736 hasRelatedWork W1997646508 @default.
• W4328112736 hasRelatedWork W1999854806 @default.
• W4328112736 hasRelatedWork W2087822253 @default.
• W4328112736 hasRelatedWork W2102989609 @default.
• W4328112736 hasRelatedWork W2118921797 @default.
• W4328112736 hasRelatedWork W2129187957 @default.
• W4328112736 hasRelatedWork W2154299143 @default.
• W4328112736 hasRelatedWork W3195074806 @default.
• W4328112736 hasRelatedWork W4315465216 @default.
• W4328112736 isParatext "false" @default.
• W4328112736 isRetracted "false" @default.
• W4328112736 workType "article" @default.