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• W4328112904 abstract "Chronic kidney disease (CKD) patients face an unacceptably high morbidity and mortality, mainly from cardiovascular diseases. Diabetes mellitus, arterial hypertension and dyslipidemia are highly prevalent in CKD patients. Established therapeutic protocols for the treatment of diabetes mellitus, arterial hypertension, and dyslipidemia are not as effective in CKD patients as in the general population. The role of non-traditional risk factors (RF) has gained interest in the last decades. These entail the deranged clinical spectrum of secondary hyperparathyroidism involving vascular and valvular calcification, under the term CKD-mineral and bone disorder (CKD-MBD), uremia per se, inflammation and oxidative stress. Each one of these non-traditional RF have been addressed in various study designs, but the results do not exhibit any applied clinical benefit for CKD-patients. The crusade against cardiorenal morbidity and mortality in CKD-patients is in some instances, derailed. We propose a therapeutic paradigm advancing from isolated treatment targets, as practiced today, to precision medicine involving patient phenotypes with distinct underlying pathophysiology. In this regard we propose two steps, based on current stratification management of corona virus disease-19 and sepsis. First, select patients who are expected to have a high mortality, i.e., a prognostic enrichment. Second, select patients who are likely to respond to a specific therapy, i.e., a predictive enrichment." @default.
• W4328112904 created "2023-03-22" @default.
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• W4328112904 date "2023-03-26" @default.
• W4328112904 modified "2023-09-26" @default.
• W4328112904 title "Redefying the therapeutic strategies against cardiorenal morbidity and mortality: Patient phenotypes" @default.
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• W4328112904 doi "https://doi.org/10.4330/wjc.v15.i3.76" @default.
• W4328112904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37033683" @default.
• W4328112904 hasPublicationYear "2023" @default.
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