Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328112914> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4328112914 abstract "Radiation-induced gliomas (RIGs) are an uncommon disease type and a known long-term complication of prior central nervous system radiation exposure, often during childhood. Given the rarity of this malignancy subtype, no clinical trials have explored optimal therapy for these patients, and the literature is primarily limited to reports of patient cases and series. Indeed, the genomic profiles of RIGs have only recently been explored in limited numbers, categorizing these gliomas into a unique subset. Here, we describe two cases of RIG diagnosed as glioblastoma (GB), IDH-wildtype, in adults who had previously received central nervous system radiation for childhood cancers. Both patients demonstrated a surprising complete radiographic response of the postoperative residual disease to front-line therapy, a phenomenon rarely observed in the management of any GB and never previously reported for the radiation-induced subgroup. Both tumors were characterized by next-generation sequencing and chromosomal microarray to identify potential etiologies for this response as well as to further add to the limited literature about the unique molecular profile of RIGs, showing signatures more consistent with diffuse pediatric-type high-grade glioma, H3-wildtype, and IDH-wildtype, WHO grade 4. Ultimately, we demonstrate that treatment utilizing a radiation-based regimen for GB in a previously radiated tissue can be highly successful despite historical limitations in the management of this disease." @default.
- W4328112914 created "2023-03-22" @default.
- W4328112914 creator A5003825991 @default.
- W4328112914 creator A5033480184 @default.
- W4328112914 creator A5048019436 @default.
- W4328112914 creator A5060720802 @default.
- W4328112914 creator A5069223063 @default.
- W4328112914 creator A5090884626 @default.
- W4328112914 date "2023-03-21" @default.
- W4328112914 modified "2023-09-25" @default.
- W4328112914 title "Case report: Radiographic complete response of radiation-induced glioblastoma to front-line radiotherapy: A report and molecular characterization of two unique cases" @default.
- W4328112914 cites W1597511577 @default.
- W4328112914 cites W1982986377 @default.
- W4328112914 cites W2005133500 @default.
- W4328112914 cites W2026732233 @default.
- W4328112914 cites W2040228072 @default.
- W4328112914 cites W2079930439 @default.
- W4328112914 cites W2096287682 @default.
- W4328112914 cites W2158681922 @default.
- W4328112914 cites W2162643152 @default.
- W4328112914 cites W2165871546 @default.
- W4328112914 cites W2778283729 @default.
- W4328112914 cites W2800438974 @default.
- W4328112914 cites W2804570055 @default.
- W4328112914 cites W2811438356 @default.
- W4328112914 cites W2890374908 @default.
- W4328112914 cites W2901978078 @default.
- W4328112914 cites W2944166449 @default.
- W4328112914 cites W2963466627 @default.
- W4328112914 cites W2990284892 @default.
- W4328112914 cites W2991449575 @default.
- W4328112914 cites W3019105595 @default.
- W4328112914 cites W3161800158 @default.
- W4328112914 cites W3174246647 @default.
- W4328112914 cites W3200173100 @default.
- W4328112914 cites W3201553964 @default.
- W4328112914 cites W3216178238 @default.
- W4328112914 cites W4295010936 @default.
- W4328112914 doi "https://doi.org/10.3389/fneur.2023.1099424" @default.
- W4328112914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37025206" @default.
- W4328112914 hasPublicationYear "2023" @default.
- W4328112914 type Work @default.
- W4328112914 citedByCount "0" @default.
- W4328112914 crossrefType "journal-article" @default.
- W4328112914 hasAuthorship W4328112914A5003825991 @default.
- W4328112914 hasAuthorship W4328112914A5033480184 @default.
- W4328112914 hasAuthorship W4328112914A5048019436 @default.
- W4328112914 hasAuthorship W4328112914A5060720802 @default.
- W4328112914 hasAuthorship W4328112914A5069223063 @default.
- W4328112914 hasAuthorship W4328112914A5090884626 @default.
- W4328112914 hasBestOaLocation W43281129141 @default.
- W4328112914 hasConcept C126838900 @default.
- W4328112914 hasConcept C142724271 @default.
- W4328112914 hasConcept C143998085 @default.
- W4328112914 hasConcept C2778227246 @default.
- W4328112914 hasConcept C2779134260 @default.
- W4328112914 hasConcept C2779399171 @default.
- W4328112914 hasConcept C2781413609 @default.
- W4328112914 hasConcept C502942594 @default.
- W4328112914 hasConcept C509974204 @default.
- W4328112914 hasConcept C71924100 @default.
- W4328112914 hasConceptScore W4328112914C126838900 @default.
- W4328112914 hasConceptScore W4328112914C142724271 @default.
- W4328112914 hasConceptScore W4328112914C143998085 @default.
- W4328112914 hasConceptScore W4328112914C2778227246 @default.
- W4328112914 hasConceptScore W4328112914C2779134260 @default.
- W4328112914 hasConceptScore W4328112914C2779399171 @default.
- W4328112914 hasConceptScore W4328112914C2781413609 @default.
- W4328112914 hasConceptScore W4328112914C502942594 @default.
- W4328112914 hasConceptScore W4328112914C509974204 @default.
- W4328112914 hasConceptScore W4328112914C71924100 @default.
- W4328112914 hasLocation W43281129141 @default.
- W4328112914 hasLocation W43281129142 @default.
- W4328112914 hasLocation W43281129143 @default.
- W4328112914 hasOpenAccess W4328112914 @default.
- W4328112914 hasPrimaryLocation W43281129141 @default.
- W4328112914 hasRelatedWork W1982245596 @default.
- W4328112914 hasRelatedWork W2065856818 @default.
- W4328112914 hasRelatedWork W2348274287 @default.
- W4328112914 hasRelatedWork W2348683779 @default.
- W4328112914 hasRelatedWork W2360237506 @default.
- W4328112914 hasRelatedWork W2365801088 @default.
- W4328112914 hasRelatedWork W2384708512 @default.
- W4328112914 hasRelatedWork W2902148150 @default.
- W4328112914 hasRelatedWork W2955000134 @default.
- W4328112914 hasRelatedWork W4231022123 @default.
- W4328112914 hasVolume "14" @default.
- W4328112914 isParatext "false" @default.
- W4328112914 isRetracted "false" @default.
- W4328112914 workType "article" @default.