FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328113557> ?p ?o ?g. }

• W4328113557 abstract "Background SARS-CoV-2 infection during pregnancy may cause adverse maternal, neonatal and placental outcomes. While tissue hypoxia is often reported in COVID-19 patients, pregnant women with anemia are suspected to be more prone to placental hypoxia-related injuries. Methods This hospital-based cross-sectional study was conducted between August-November 2021, during COVID-19 second wave in India. Term pregnant women (N=212) admitted to hospital for delivery were enrolled consecutively. Since hospital admission mandated negative RT-PCR test for SARS-CoV-2 virus, none had active infection. Data on socio-demography, COVID-19 history, maternal, obstetric, and neonatal outcomes were recorded. Pre-delivery maternal and post-delivery cord blood samples were tested for hematological parameters and SARS-CoV-2 IgG. Placentae were studied for histology. Results Of 212 women, 122 (58%) were seropositive for SARS-CoV-2 IgG, but none reported COVID-19 history; 134 (63.2%) were anemic. In seropositive women, hemoglobin ( p =0.04), total WBC ( p =0.009), lymphocytes ( p =0.005) and neutrophils ( p =0.02) were significantly higher, while ferritin was high, but not significant and neutrophils to lymphocytes ( p =0.12) and platelets to lymphocytes ratios ( p =0.03) were lower. Neonatal outcomes were similar. All RBC parameters and serum ferritin were significantly lower in anemic mothers but not in cord blood, except RDW that was significantly higher in both, maternal ( p =0.007) and cord ( p =0.008) blood from seropositive anemic group compared to other groups. Placental histology showed significant increase in villous hypervascularity ( p =0.000), dilated villous capillaries ( p =0.000), and syncytiotrophoblasts ( p =0.02) in seropositive group, typically suggesting placental hypoxia. Maternal anemia was not associated with any histological parameters. Univariate and multivariate logistic regression analyses of placental histopathological adverse outcomes showed strong association with SARS-CoV-2 seropositivity but not with maternal anemia. When adjusted for several covariates, including anemia, SARS-CoV-2 seropositivity emerged as independent risk factor for severe chorangiosis (AOR 8.74, 95% CI 3.51-21.76, p &lt;0.000), dilated blood vessels (AOR 12.74, 95% CI 5.46-29.75, p &lt;0.000), syncytiotrophoblasts (AOR 2.86, 95% CI 1.36-5.99, p =0.005) and villus agglutination (AOR 9.27, 95% CI 3.68-23.32, p &lt;0.000). Conclusion Asymptomatic COVID-19 during pregnancy seemed to be associated with various abnormal placental histopathologic changes related to placental hypoxia independent of maternal anemia status. Our data supports an independent role of SARS-CoV-2 in causing placental hypoxia in pregnant women." @default.
• W4328113557 created "2023-03-22" @default.
• W4328113557 creator A5015737554 @default.
• W4328113557 creator A5022492890 @default.
• W4328113557 creator A5029442879 @default.
• W4328113557 creator A5046940034 @default.
• W4328113557 creator A5054367391 @default.
• W4328113557 creator A5064203778 @default.
• W4328113557 creator A5064759803 @default.
• W4328113557 creator A5081316243 @default.
• W4328113557 creator A5083053307 @default.
• W4328113557 creator A5089418716 @default.
• W4328113557 creator A5090104384 @default.
• W4328113557 date "2023-03-21" @default.
• W4328113557 modified "2023-09-30" @default.
• W4328113557 title "Impact of COVID-19 during pregnancy on placental pathology, maternal and neonatal outcome – A cross-sectional study on anemic term pregnant women from a tertiary care hospital in southern India" @default.
• W4328113557 cites W1588774717 @default.
• W4328113557 cites W1802211212 @default.
• W4328113557 cites W2000795003 @default.
• W4328113557 cites W2026880835 @default.
• W4328113557 cites W2050021334 @default.
• W4328113557 cites W2081192013 @default.
• W4328113557 cites W2087625202 @default.
• W4328113557 cites W2131688861 @default.
• W4328113557 cites W2132961242 @default.
• W4328113557 cites W2399942170 @default.
• W4328113557 cites W2542914126 @default.
• W4328113557 cites W2996013111 @default.
• W4328113557 cites W3001118548 @default.
• W4328113557 cites W3003668884 @default.
• W4328113557 cites W3005113694 @default.
• W4328113557 cites W3009365815 @default.
• W4328113557 cites W3011829798 @default.
• W4328113557 cites W3012611938 @default.
• W4328113557 cites W3012907794 @default.
• W4328113557 cites W3013865747 @default.
• W4328113557 cites W3014534620 @default.
• W4328113557 cites W3015130991 @default.
• W4328113557 cites W3016259199 @default.
• W4328113557 cites W3016273932 @default.
• W4328113557 cites W3017027582 @default.
• W4328113557 cites W3017743621 @default.
• W4328113557 cites W3017836790 @default.
• W4328113557 cites W3017852069 @default.
• W4328113557 cites W3019841802 @default.
• W4328113557 cites W3019956037 @default.
• W4328113557 cites W3022611835 @default.
• W4328113557 cites W3025423046 @default.
• W4328113557 cites W3026144150 @default.
• W4328113557 cites W3033139595 @default.
• W4328113557 cites W3036931136 @default.
• W4328113557 cites W3037517165 @default.
• W4328113557 cites W3040403293 @default.
• W4328113557 cites W3041628487 @default.
• W4328113557 cites W3043894438 @default.
• W4328113557 cites W3044953937 @default.
• W4328113557 cites W3046282146 @default.
• W4328113557 cites W3048519565 @default.
• W4328113557 cites W3081450276 @default.
• W4328113557 cites W3082832067 @default.
• W4328113557 cites W3087390394 @default.
• W4328113557 cites W3092110990 @default.
• W4328113557 cites W3093106152 @default.
• W4328113557 cites W3097657056 @default.
• W4328113557 cites W3102885302 @default.
• W4328113557 cites W3107847487 @default.
• W4328113557 cites W3112129322 @default.
• W4328113557 cites W3121906900 @default.
• W4328113557 cites W3127706454 @default.
• W4328113557 cites W3134942922 @default.
• W4328113557 cites W3162289579 @default.
• W4328113557 cites W3163246137 @default.
• W4328113557 cites W3165656738 @default.
• W4328113557 cites W3182484993 @default.
• W4328113557 cites W3199103568 @default.
• W4328113557 cites W4200120717 @default.
• W4328113557 cites W4200184323 @default.
• W4328113557 cites W4206812716 @default.
• W4328113557 cites W4212821069 @default.
• W4328113557 cites W4232080486 @default.
• W4328113557 cites W4234605001 @default.
• W4328113557 cites W4289711074 @default.
• W4328113557 cites W4296363572 @default.
• W4328113557 cites W4296793792 @default.
• W4328113557 doi "https://doi.org/10.3389/fendo.2023.1092104" @default.
• W4328113557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37025411" @default.
• W4328113557 hasPublicationYear "2023" @default.
• W4328113557 type Work @default.
• W4328113557 citedByCount "1" @default.
• W4328113557 countsByYear W43281135572023 @default.
• W4328113557 crossrefType "journal-article" @default.
• W4328113557 hasAuthorship W4328113557A5015737554 @default.
• W4328113557 hasAuthorship W4328113557A5022492890 @default.
• W4328113557 hasAuthorship W4328113557A5029442879 @default.
• W4328113557 hasAuthorship W4328113557A5046940034 @default.
• W4328113557 hasAuthorship W4328113557A5054367391 @default.
• W4328113557 hasAuthorship W4328113557A5064203778 @default.
• W4328113557 hasAuthorship W4328113557A5064759803 @default.
• W4328113557 hasAuthorship W4328113557A5081316243 @default.
• W4328113557 hasAuthorship W4328113557A5083053307 @default.

• next