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• W4328113575 abstract "SET domain-containing 2 (SETD2) is a lysine methyltransferase that catalyzes histone H3 lysine36 trimethylation (H3K36me3) and has been revealed to play important roles in the regulation of transcriptional elongation, RNA splicing, and DNA damage repair. SETD2 mutations have been documented in several cancers, including clear cell renal cell carcinoma (ccRCC). SETD2 deficiency is associated with cancer occurrence and progression by regulating autophagy flux, general metabolic activity, and replication fork speed. Therefore, SETD2 is considered a potential epigenetic therapeutic target and is the subject of ongoing research on cancer-related diagnosis and treatment. This review presents an overview of the molecular functions of SETD2 in H3K36me3 regulation and its relationship with ccRCC, providing a theoretical basis for subsequent antitumor therapy based on SETD2 or H3K36me3 targets." @default.
• W4328113575 created "2023-03-22" @default.
• W4328113575 creator A5003746108 @default.
• W4328113575 creator A5030921116 @default.
• W4328113575 creator A5049407304 @default.
• W4328113575 creator A5057136525 @default.
• W4328113575 creator A5067899887 @default.
• W4328113575 creator A5076763144 @default.
• W4328113575 date "2023-03-21" @default.
• W4328113575 modified "2023-09-23" @default.
• W4328113575 title "Histone methyltransferase SETD2: An epigenetic driver in clear cell renal cell carcinoma" @default.
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