Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328114243> ?p ?o ?g. }
- W4328114243 abstract "Androgen and androgen deprivation (castration) therapies, including androgen receptor antagonists, are clinically used to treat patients with prostate cancer. However, most hormone-dependent prostate cancer patients progress into a malignant state with loss of hormone-dependency, known as castration (drug)-resistant prostate cancer (CRPC), after prolong androgen-based treatments. Even in the CRPC state with irreversible malignancy, androgen receptor (AR) expression is detectable. An epigenetic transition to CRPC induced by the action of AR-mediated androgen could be speculated in the patients with prostate cancer. Androgen receptors belongs to the nuclear receptor superfamily with 48 members in humans, and acts as a ligand-dependent transcriptional factor, leading to local chromatin reorganization for ligand-dependent gene regulation. In this review, we discussed the transcriptional/epigenetic regulatory functions of AR, with emphasis on the clinical applications of AR ligands, AR protein co-regulators, and AR RNA coregulator (enhancer RNA), especially in chromatin reorganization, in patients with prostate cancer." @default.
- W4328114243 created "2023-03-22" @default.
- W4328114243 creator A5003483247 @default.
- W4328114243 creator A5003797388 @default.
- W4328114243 creator A5027044231 @default.
- W4328114243 creator A5040328741 @default.
- W4328114243 date "2023-03-21" @default.
- W4328114243 modified "2023-09-30" @default.
- W4328114243 title "The epigenetic function of androgen receptor in prostate cancer progression" @default.
- W4328114243 cites W1821522531 @default.
- W4328114243 cites W1831392484 @default.
- W4328114243 cites W1972459670 @default.
- W4328114243 cites W1976701714 @default.
- W4328114243 cites W1977027014 @default.
- W4328114243 cites W1991995900 @default.
- W4328114243 cites W1994644909 @default.
- W4328114243 cites W1995226230 @default.
- W4328114243 cites W1996739656 @default.
- W4328114243 cites W1999673859 @default.
- W4328114243 cites W2002653885 @default.
- W4328114243 cites W2009858080 @default.
- W4328114243 cites W2020265106 @default.
- W4328114243 cites W2028372813 @default.
- W4328114243 cites W2030521036 @default.
- W4328114243 cites W2033439599 @default.
- W4328114243 cites W2036001944 @default.
- W4328114243 cites W2036388991 @default.
- W4328114243 cites W2041825762 @default.
- W4328114243 cites W2053961392 @default.
- W4328114243 cites W2054621094 @default.
- W4328114243 cites W2055296531 @default.
- W4328114243 cites W2064255634 @default.
- W4328114243 cites W2065851522 @default.
- W4328114243 cites W2068205741 @default.
- W4328114243 cites W2071914496 @default.
- W4328114243 cites W2072722847 @default.
- W4328114243 cites W2073769648 @default.
- W4328114243 cites W2073933425 @default.
- W4328114243 cites W2074496710 @default.
- W4328114243 cites W2074971523 @default.
- W4328114243 cites W2076900250 @default.
- W4328114243 cites W2081557764 @default.
- W4328114243 cites W2085005232 @default.
- W4328114243 cites W2085667285 @default.
- W4328114243 cites W2089518544 @default.
- W4328114243 cites W2090333443 @default.
- W4328114243 cites W2090805227 @default.
- W4328114243 cites W2092783245 @default.
- W4328114243 cites W2094221767 @default.
- W4328114243 cites W2096643907 @default.
- W4328114243 cites W2098848421 @default.
- W4328114243 cites W2107372115 @default.
- W4328114243 cites W2107558077 @default.
- W4328114243 cites W2114033366 @default.
- W4328114243 cites W2114448119 @default.
- W4328114243 cites W2121098984 @default.
- W4328114243 cites W2126068460 @default.
- W4328114243 cites W2126315841 @default.
- W4328114243 cites W2126496338 @default.
- W4328114243 cites W2127996002 @default.
- W4328114243 cites W2129651872 @default.
- W4328114243 cites W2130211801 @default.
- W4328114243 cites W2132049525 @default.
- W4328114243 cites W2133148543 @default.
- W4328114243 cites W2136694266 @default.
- W4328114243 cites W2146027649 @default.
- W4328114243 cites W2148643283 @default.
- W4328114243 cites W2148683590 @default.
- W4328114243 cites W2151445954 @default.
- W4328114243 cites W2151867303 @default.
- W4328114243 cites W2156923287 @default.
- W4328114243 cites W2161439053 @default.
- W4328114243 cites W2164236134 @default.
- W4328114243 cites W2166037178 @default.
- W4328114243 cites W2168842195 @default.
- W4328114243 cites W2169391650 @default.
- W4328114243 cites W2172256092 @default.
- W4328114243 cites W2224655222 @default.
- W4328114243 cites W2281629727 @default.
- W4328114243 cites W2295037017 @default.
- W4328114243 cites W2404460725 @default.
- W4328114243 cites W2405684830 @default.
- W4328114243 cites W2507643563 @default.
- W4328114243 cites W2561840259 @default.
- W4328114243 cites W2563248582 @default.
- W4328114243 cites W2580542642 @default.
- W4328114243 cites W2758743773 @default.
- W4328114243 cites W2765669897 @default.
- W4328114243 cites W2807985734 @default.
- W4328114243 cites W2808687910 @default.
- W4328114243 cites W2883902554 @default.
- W4328114243 cites W2884617552 @default.
- W4328114243 cites W2885209431 @default.
- W4328114243 cites W2888204653 @default.
- W4328114243 cites W2892569542 @default.
- W4328114243 cites W2903363757 @default.
- W4328114243 cites W2912662942 @default.
- W4328114243 cites W2920174847 @default.
- W4328114243 cites W2930921491 @default.
- W4328114243 cites W2950463295 @default.