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- W4328114932 abstract "Abstract Late‐stage diversification of drug molecules is an important strategy in drug discovery that can be facilitated by reaction screening using high‐throughput experimentation. Here we present a rapid method for functionalizing bioactive molecules based on accelerated reactions in microdroplets. Reaction mixtures are nebulized at throughputs better than 1 reaction/second and the accelerated reactions occurring in the microdroplets are followed by desorption electrospray ionization mass spectrometry (DESI‐MS). Because the accelerated reactions occur on the millisecond timescale, they allow an overall screening throughput of 1 Hz working at the low nanogram scale. Using this approach, an opioid agonist (PZM21) and an antagonist (naloxone) were diversified using three reactions important in medicinal chemistry: sulfur fluoride exchange (SuFEx) click reactions, imine formation reactions, and ene‐type click reactions. Some 269 functionalized analogs of naloxone and PZM21 were generated and characterized by tandem mass spectrometry (MS/MS) after screening over 500 reactions." @default.
- W4328114932 created "2023-03-22" @default.
- W4328114932 creator A5004968004 @default.
- W4328114932 creator A5007656279 @default.
- W4328114932 creator A5071041689 @default.
- W4328114932 creator A5077927752 @default.
- W4328114932 date "2023-04-20" @default.
- W4328114932 modified "2023-10-09" @default.
- W4328114932 title "High‐Throughput Diversification of Complex Bioactive Molecules by Accelerated Synthesis in Microdroplets" @default.
- W4328114932 cites W1956858148 @default.
- W4328114932 cites W1980491680 @default.
- W4328114932 cites W1989688131 @default.
- W4328114932 cites W1991463958 @default.
- W4328114932 cites W2002874263 @default.
- W4328114932 cites W2011074581 @default.
- W4328114932 cites W2021395631 @default.
- W4328114932 cites W2025804869 @default.
- W4328114932 cites W2031441006 @default.
- W4328114932 cites W2086112748 @default.
- W4328114932 cites W2090734571 @default.
- W4328114932 cites W2100952570 @default.
- W4328114932 cites W2101936201 @default.
- W4328114932 cites W2119039945 @default.
- W4328114932 cites W2121324049 @default.
- W4328114932 cites W2137890896 @default.
- W4328114932 cites W2157520165 @default.
- W4328114932 cites W2377887541 @default.
- W4328114932 cites W2396061637 @default.
- W4328114932 cites W2512351034 @default.
- W4328114932 cites W2512819857 @default.
- W4328114932 cites W2589168356 @default.
- W4328114932 cites W2616399381 @default.
- W4328114932 cites W2617279801 @default.
- W4328114932 cites W2769457208 @default.
- W4328114932 cites W2769763900 @default.
- W4328114932 cites W2781732623 @default.
- W4328114932 cites W2784918212 @default.
- W4328114932 cites W2786943411 @default.
- W4328114932 cites W2804307771 @default.
- W4328114932 cites W2808710259 @default.
- W4328114932 cites W2887803294 @default.
- W4328114932 cites W2898455017 @default.
- W4328114932 cites W2905686003 @default.
- W4328114932 cites W2911199588 @default.
- W4328114932 cites W2913545583 @default.
- W4328114932 cites W2919807292 @default.
- W4328114932 cites W2944148756 @default.
- W4328114932 cites W2964588072 @default.
- W4328114932 cites W2965448259 @default.
- W4328114932 cites W2967848469 @default.
- W4328114932 cites W2968468162 @default.
- W4328114932 cites W2971299686 @default.
- W4328114932 cites W2971850243 @default.
- W4328114932 cites W2972520967 @default.
- W4328114932 cites W3011093135 @default.
- W4328114932 cites W3017097444 @default.
- W4328114932 cites W3017783322 @default.
- W4328114932 cites W3021718036 @default.
- W4328114932 cites W3029520338 @default.
- W4328114932 cites W3031984292 @default.
- W4328114932 cites W3034389841 @default.
- W4328114932 cites W3038659748 @default.
- W4328114932 cites W3045705195 @default.
- W4328114932 cites W3046908777 @default.
- W4328114932 cites W3049273828 @default.
- W4328114932 cites W3075563446 @default.
- W4328114932 cites W3089015928 @default.
- W4328114932 cites W3092451719 @default.
- W4328114932 cites W3103309778 @default.
- W4328114932 cites W3108955872 @default.
- W4328114932 cites W3117675194 @default.
- W4328114932 cites W3120896887 @default.
- W4328114932 cites W3131770529 @default.
- W4328114932 cites W3137038992 @default.
- W4328114932 cites W3158784047 @default.
- W4328114932 cites W3162215856 @default.
- W4328114932 cites W3183373438 @default.
- W4328114932 cites W3195172060 @default.
- W4328114932 cites W3198222057 @default.
- W4328114932 cites W3203585464 @default.
- W4328114932 cites W3210815937 @default.
- W4328114932 cites W3216795475 @default.
- W4328114932 cites W4206253369 @default.
- W4328114932 cites W4210725400 @default.
- W4328114932 cites W4213455009 @default.
- W4328114932 cites W4220670959 @default.
- W4328114932 cites W4220831272 @default.
- W4328114932 cites W4224547524 @default.
- W4328114932 cites W4229444102 @default.
- W4328114932 cites W4233555431 @default.
- W4328114932 cites W4250159618 @default.
- W4328114932 cites W4289654098 @default.
- W4328114932 cites W4292656533 @default.
- W4328114932 cites W4306658370 @default.
- W4328114932 cites W4308439889 @default.
- W4328114932 cites W4327957694 @default.
- W4328114932 cites W4362231430 @default.
- W4328114932 cites W2644804608 @default.
- W4328114932 doi "https://doi.org/10.1002/ange.202300956" @default.
- W4328114932 hasPublicationYear "2023" @default.