FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328114952> ?p ?o ?g. }

• W4328114952 abstract "Background: Field potential (FP) signals from human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) spheroid which are used for drug safety tests in the preclinical stage are different from action potential (AP) signals and require working knowledge of the multi-electrode array (MEA) system. In this study, we developed in silico three-dimensional (3-D) models of hiPSC-CM spheroids for the simulation of field potential measurement. We compared our model simulation results against in vitro experimental data under the effect of drugs E-4031 and nifedipine. Methods:In silico 3-D models of hiPSC-CM spheroids were constructed in spherical and discoidal shapes. Tetrahedral meshes were generated inside the models, and the propagation of the action potential in the model was obtained by numerically solving the monodomain reaction-diffusion equation. An electrical model of electrode was constructed and FPs were calculated using the extracellular potentials from the AP propagations. The effects of drugs were simulated by matching the simulation results with in vitro experimental data. Results: The simulated FPs from the 3-D models of hiPSC-CM spheroids exhibited highly variable shapes depending on the stimulation and measurement locations. The values of the IC50 of E-4031 and nifedipine calculated by matching the simulated FP durations with in vitro experimental data were in line with the experimentally measured ones reported in the literature. Conclusion: The 3-D in silico models of hiPSC-CM spheroids generated highly variable FPs similar to those observed in in vitro experiments. The in silico model has the potential to complement the interpretation of the FP signals obtained from in vitro experiments." @default.
• W4328114952 created "2023-03-22" @default.
• W4328114952 creator A5008271894 @default.
• W4328114952 creator A5039944153 @default.
• W4328114952 creator A5040708060 @default.
• W4328114952 creator A5065707071 @default.
• W4328114952 creator A5079104884 @default.
• W4328114952 date "2023-03-21" @default.
• W4328114952 modified "2023-10-01" @default.
• W4328114952 title "The three-dimensionality of the hiPSC-CM spheroid contributes to the variability of the field potential" @default.
• W4328114952 cites W1795050634 @default.
• W4328114952 cites W1974119618 @default.
• W4328114952 cites W2009916207 @default.
• W4328114952 cites W2011971695 @default.
• W4328114952 cites W2035312069 @default.
• W4328114952 cites W2038935943 @default.
• W4328114952 cites W2039528791 @default.
• W4328114952 cites W2064065924 @default.
• W4328114952 cites W2066130742 @default.
• W4328114952 cites W2073921281 @default.
• W4328114952 cites W2085048839 @default.
• W4328114952 cites W2115765852 @default.
• W4328114952 cites W2121399822 @default.
• W4328114952 cites W2126928912 @default.
• W4328114952 cites W2141241503 @default.
• W4328114952 cites W2196158458 @default.
• W4328114952 cites W2328454508 @default.
• W4328114952 cites W2341385452 @default.
• W4328114952 cites W2527750418 @default.
• W4328114952 cites W2560447818 @default.
• W4328114952 cites W2579970354 @default.
• W4328114952 cites W2596518358 @default.
• W4328114952 cites W2607618862 @default.
• W4328114952 cites W2735818838 @default.
• W4328114952 cites W2745870743 @default.
• W4328114952 cites W2753476744 @default.
• W4328114952 cites W2762201289 @default.
• W4328114952 cites W2770578593 @default.
• W4328114952 cites W2774069831 @default.
• W4328114952 cites W2780483013 @default.
• W4328114952 cites W2786635794 @default.
• W4328114952 cites W2810580674 @default.
• W4328114952 cites W2941656913 @default.
• W4328114952 cites W2952947444 @default.
• W4328114952 cites W2969287584 @default.
• W4328114952 cites W2981031120 @default.
• W4328114952 cites W2981763338 @default.
• W4328114952 cites W3004299218 @default.
• W4328114952 cites W3028025305 @default.
• W4328114952 cites W3089475890 @default.
• W4328114952 cites W3092426606 @default.
• W4328114952 cites W3123833583 @default.
• W4328114952 cites W3130522032 @default.
• W4328114952 cites W3134164720 @default.
• W4328114952 cites W3157651290 @default.
• W4328114952 cites W3186768463 @default.
• W4328114952 cites W4220893378 @default.
• W4328114952 cites W992080595 @default.
• W4328114952 doi "https://doi.org/10.3389/fphys.2023.1123190" @default.
• W4328114952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37025386" @default.
• W4328114952 hasPublicationYear "2023" @default.
• W4328114952 type Work @default.
• W4328114952 citedByCount "0" @default.
• W4328114952 crossrefType "journal-article" @default.
• W4328114952 hasAuthorship W4328114952A5008271894 @default.
• W4328114952 hasAuthorship W4328114952A5039944153 @default.
• W4328114952 hasAuthorship W4328114952A5040708060 @default.
• W4328114952 hasAuthorship W4328114952A5065707071 @default.
• W4328114952 hasAuthorship W4328114952A5079104884 @default.
• W4328114952 hasBestOaLocation W43281149521 @default.
• W4328114952 hasConcept C104317684 @default.
• W4328114952 hasConcept C117838684 @default.
• W4328114952 hasConcept C12554922 @default.
• W4328114952 hasConcept C136229726 @default.
• W4328114952 hasConcept C169760540 @default.
• W4328114952 hasConcept C175369904 @default.
• W4328114952 hasConcept C185592680 @default.
• W4328114952 hasConcept C186060115 @default.
• W4328114952 hasConcept C192562407 @default.
• W4328114952 hasConcept C202751555 @default.
• W4328114952 hasConcept C2775905019 @default.
• W4328114952 hasConcept C41008148 @default.
• W4328114952 hasConcept C55493867 @default.
• W4328114952 hasConcept C71924100 @default.
• W4328114952 hasConcept C86803240 @default.
• W4328114952 hasConceptScore W4328114952C104317684 @default.
• W4328114952 hasConceptScore W4328114952C117838684 @default.
• W4328114952 hasConceptScore W4328114952C12554922 @default.
• W4328114952 hasConceptScore W4328114952C136229726 @default.
• W4328114952 hasConceptScore W4328114952C169760540 @default.
• W4328114952 hasConceptScore W4328114952C175369904 @default.
• W4328114952 hasConceptScore W4328114952C185592680 @default.
• W4328114952 hasConceptScore W4328114952C186060115 @default.
• W4328114952 hasConceptScore W4328114952C192562407 @default.
• W4328114952 hasConceptScore W4328114952C202751555 @default.
• W4328114952 hasConceptScore W4328114952C2775905019 @default.
• W4328114952 hasConceptScore W4328114952C41008148 @default.
• W4328114952 hasConceptScore W4328114952C55493867 @default.
• W4328114952 hasConceptScore W4328114952C71924100 @default.
• W4328114952 hasConceptScore W4328114952C86803240 @default.

• next