Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328115528> ?p ?o ?g. }
- W4328115528 abstract "Introduction: Forkhead (FOX) transcription factors are involved in cell cycle control, cellular differentiation, maintenance of tissues, and aging. Mutation or aberrant expression of FOX proteins is associated with developmental disorders and cancers. FOXM1, an oncogenic transcription factor, is a promoter of cell proliferation and accelerated development of breast adenocarcinomas, squamous carcinoma of the head, neck, and cervix, and nasopharyngeal carcinoma. High FOXM1 expression is correlated with chemoresistance in patients treated with doxorubicin and Epirubicin by enhancing the DNA repair in breast cancer cells. Method: miRNA-seq identified downregulation of miR-4521 in breast cancer cell lines. Stable miR-4521 overexpressing breast cancer cell lines (MCF-7, MDA-MB-468) were developed to identify miR-4521 target gene and function in breast cancer. Results: Here, we showed that FOXM1 is a direct target of miR-4521 in breast cancer. Overexpression of miR-4521 significantly downregulated FOXM1 expression in breast cancer cells. FOXM1 regulates cell cycle progression and DNA damage response in breast cancer. We showed that miR-4521 expression leads to increased ROS levels and DNA damage in breast cancer cells. FOXM1 plays a critical role in ROS scavenging and promotes stemness which contributes to drug resistance in breast cancer. We observed that breast cancer cells stably expressing miR-4521 lead to cell cycle arrest, impaired FOXM1 mediated DNA damage response leading to increased cell death in breast cancer cells. Additionally, miR-4521-mediated FOXM1 downregulation perturbs cell proliferation, invasion, cell cycle progression, and epithelial-to-mesenchymal progression (EMT) in breast cancer. Discussion: High FOXM1 expression has been associated with radio and chemoresistance contributing to poor patient survival in multiple cancers, including breast cancer. Our study showed that FOXM1 mediated DNA damage response could be targeted using miR-4521 mimics as a novel therapeutic for breast cancer." @default.
- W4328115528 created "2023-03-22" @default.
- W4328115528 creator A5028873616 @default.
- W4328115528 creator A5038485029 @default.
- W4328115528 creator A5043234004 @default.
- W4328115528 creator A5047067057 @default.
- W4328115528 creator A5048054998 @default.
- W4328115528 creator A5052363702 @default.
- W4328115528 creator A5054283209 @default.
- W4328115528 creator A5073676954 @default.
- W4328115528 date "2023-03-21" @default.
- W4328115528 modified "2023-10-14" @default.
- W4328115528 title "MiR-4521 perturbs FOXM1-mediated DNA damage response in breast cancer" @default.
- W4328115528 cites W1764201319 @default.
- W4328115528 cites W2001479656 @default.
- W4328115528 cites W2002512110 @default.
- W4328115528 cites W2014574284 @default.
- W4328115528 cites W2017199818 @default.
- W4328115528 cites W2017593987 @default.
- W4328115528 cites W2028748220 @default.
- W4328115528 cites W2034091087 @default.
- W4328115528 cites W2044702943 @default.
- W4328115528 cites W2053664200 @default.
- W4328115528 cites W2093676592 @default.
- W4328115528 cites W2096283457 @default.
- W4328115528 cites W2098860663 @default.
- W4328115528 cites W2114843025 @default.
- W4328115528 cites W2125569277 @default.
- W4328115528 cites W2134150856 @default.
- W4328115528 cites W2134629862 @default.
- W4328115528 cites W2136741329 @default.
- W4328115528 cites W2137449882 @default.
- W4328115528 cites W2149264287 @default.
- W4328115528 cites W2149442044 @default.
- W4328115528 cites W2156246476 @default.
- W4328115528 cites W2163569233 @default.
- W4328115528 cites W2166240615 @default.
- W4328115528 cites W2171293990 @default.
- W4328115528 cites W2171664056 @default.
- W4328115528 cites W2230219611 @default.
- W4328115528 cites W2292378658 @default.
- W4328115528 cites W2460753863 @default.
- W4328115528 cites W2560367415 @default.
- W4328115528 cites W2563046503 @default.
- W4328115528 cites W2568079606 @default.
- W4328115528 cites W2623745775 @default.
- W4328115528 cites W2765219164 @default.
- W4328115528 cites W2799715163 @default.
- W4328115528 cites W2803650969 @default.
- W4328115528 cites W2890410994 @default.
- W4328115528 cites W2917187119 @default.
- W4328115528 cites W2939860816 @default.
- W4328115528 cites W2945942484 @default.
- W4328115528 cites W2969206702 @default.
- W4328115528 cites W2974278475 @default.
- W4328115528 cites W2978416675 @default.
- W4328115528 cites W2983068713 @default.
- W4328115528 cites W2991511143 @default.
- W4328115528 cites W2997565244 @default.
- W4328115528 cites W3010619009 @default.
- W4328115528 cites W3012576124 @default.
- W4328115528 cites W3028827854 @default.
- W4328115528 cites W3082143929 @default.
- W4328115528 cites W3087060817 @default.
- W4328115528 cites W3120885630 @default.
- W4328115528 cites W3127406407 @default.
- W4328115528 cites W3131682687 @default.
- W4328115528 cites W3199525603 @default.
- W4328115528 cites W3214230819 @default.
- W4328115528 cites W4221107252 @default.
- W4328115528 doi "https://doi.org/10.3389/fmolb.2023.1131433" @default.
- W4328115528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37025658" @default.
- W4328115528 hasPublicationYear "2023" @default.
- W4328115528 type Work @default.
- W4328115528 citedByCount "0" @default.
- W4328115528 crossrefType "journal-article" @default.
- W4328115528 hasAuthorship W4328115528A5028873616 @default.
- W4328115528 hasAuthorship W4328115528A5038485029 @default.
- W4328115528 hasAuthorship W4328115528A5043234004 @default.
- W4328115528 hasAuthorship W4328115528A5047067057 @default.
- W4328115528 hasAuthorship W4328115528A5048054998 @default.
- W4328115528 hasAuthorship W4328115528A5052363702 @default.
- W4328115528 hasAuthorship W4328115528A5054283209 @default.
- W4328115528 hasAuthorship W4328115528A5073676954 @default.
- W4328115528 hasBestOaLocation W43281155281 @default.
- W4328115528 hasConcept C105696609 @default.
- W4328115528 hasConcept C121608353 @default.
- W4328115528 hasConcept C126322002 @default.
- W4328115528 hasConcept C143425029 @default.
- W4328115528 hasConcept C170240278 @default.
- W4328115528 hasConcept C29537977 @default.
- W4328115528 hasConcept C502942594 @default.
- W4328115528 hasConcept C530470458 @default.
- W4328115528 hasConcept C54355233 @default.
- W4328115528 hasConcept C552990157 @default.
- W4328115528 hasConcept C62112901 @default.
- W4328115528 hasConcept C71924100 @default.
- W4328115528 hasConcept C86803240 @default.
- W4328115528 hasConceptScore W4328115528C105696609 @default.
- W4328115528 hasConceptScore W4328115528C121608353 @default.