FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328116771> ?p ?o ?g. }

• W4328116771 abstract "Prolonged exposure to general anesthetics during development is known to cause neurobehavioral abnormalities, but the cellular and molecular mechanisms involved are unclear. Microglia are the resident immune cells in the central nervous system and play essential roles in normal brain development.In the study, postnatal day 7 (P7) C57BL/6 mice were randomly assigned to two groups. In the sevoflurane (SEVO), mice were exposed to 2.5% sevoflurane for 4 h. In the control group, mice were exposed to carrier gas (30% O2/70% N2) for 4 h. Fixed brain slices from P14 to P21 mice were immunolabeled for ionized calcium-binding adapter molecule 1 (IBA-1) to visualize microglia. The morphological analysis of microglia in the somatosensory cortex was performed using ImageJ and Imaris software. Serial block face scanning electron microscopy (SBF-SEM) was performed to assess the ultrastructure of the microglia and the contacts between microglia and synapse in P14 and P21 mice. The confocal imaging of brain slices was performed to assess microglia surveillance in resting and activated states in P14 and P21 mice. Behavioral tests were used to assess the effect of microglia depletion and repopulation on neurobehavioral abnormalities caused by sevoflurane exposure.The prolonged exposure of neonatal mice to sevoflurane induced microglia hyper-ramification with an increase in total branch length, arborization area, and branch complexity 14 days after exposure. Prolonged neonatal sevoflurane exposure reduced contacts between microglia and synapses, without affecting the surveillance of microglia in the resting state or responding to laser-induced focal brain injury. These neonatal changes in microglia were associated with anxiety-like behaviors in adult mice. Furthermore, microglial depletion before sevoflurane exposure and subsequent repopulation in the neonatal brain mitigated anxiety-like behaviors caused by sevoflurane exposure.Our experiments indicate that general anesthetics may harm the developing brain, and microglia may be an essential target of general anesthetic-related developmental neurotoxicity." @default.
• W4328116771 created "2023-03-22" @default.
• W4328116771 creator A5006250732 @default.
• W4328116771 creator A5010618113 @default.
• W4328116771 creator A5014068004 @default.
• W4328116771 creator A5022395038 @default.
• W4328116771 creator A5037677450 @default.
• W4328116771 creator A5040798172 @default.
• W4328116771 creator A5061360600 @default.
• W4328116771 creator A5062280178 @default.
• W4328116771 creator A5080631054 @default.
• W4328116771 date "2023-03-21" @default.
• W4328116771 modified "2023-09-27" @default.
• W4328116771 title "Prolonged exposure of neonatal mice to sevoflurane leads to hyper-ramification in microglia, reduced contacts between microglia and synapses, and defects in adult behavior" @default.
• W4328116771 cites W1914782230 @default.
• W4328116771 cites W1980789245 @default.
• W4328116771 cites W1996024251 @default.
• W4328116771 cites W2003674452 @default.
• W4328116771 cites W2036450246 @default.
• W4328116771 cites W2036650593 @default.
• W4328116771 cites W2040675974 @default.
• W4328116771 cites W2063586074 @default.
• W4328116771 cites W2066943555 @default.
• W4328116771 cites W2069498125 @default.
• W4328116771 cites W2070059007 @default.
• W4328116771 cites W2070934930 @default.
• W4328116771 cites W2078056221 @default.
• W4328116771 cites W2085477318 @default.
• W4328116771 cites W2087826027 @default.
• W4328116771 cites W2094660330 @default.
• W4328116771 cites W2104431737 @default.
• W4328116771 cites W2122828560 @default.
• W4328116771 cites W2131532643 @default.
• W4328116771 cites W2136894044 @default.
• W4328116771 cites W2140594985 @default.
• W4328116771 cites W2151368477 @default.
• W4328116771 cites W2152914442 @default.
• W4328116771 cites W2158505111 @default.
• W4328116771 cites W2162648242 @default.
• W4328116771 cites W2206933179 @default.
• W4328116771 cites W2232962770 @default.
• W4328116771 cites W2417970798 @default.
• W4328116771 cites W2437899876 @default.
• W4328116771 cites W2509907732 @default.
• W4328116771 cites W2527645962 @default.
• W4328116771 cites W2528073273 @default.
• W4328116771 cites W2607000277 @default.
• W4328116771 cites W2624934104 @default.
• W4328116771 cites W2731100712 @default.
• W4328116771 cites W2738391310 @default.
• W4328116771 cites W2776223742 @default.
• W4328116771 cites W2778588255 @default.
• W4328116771 cites W2800927112 @default.
• W4328116771 cites W2889877535 @default.
• W4328116771 cites W2944206821 @default.
• W4328116771 cites W2948168560 @default.
• W4328116771 cites W2969700256 @default.
• W4328116771 cites W2981347614 @default.
• W4328116771 cites W2988011213 @default.
• W4328116771 cites W3007328956 @default.
• W4328116771 cites W3008888521 @default.
• W4328116771 cites W3089379338 @default.
• W4328116771 cites W3137335006 @default.
• W4328116771 cites W3137911402 @default.
• W4328116771 cites W3167987798 @default.
• W4328116771 cites W3183899443 @default.
• W4328116771 cites W3201153492 @default.
• W4328116771 cites W3201995754 @default.
• W4328116771 cites W4210981518 @default.
• W4328116771 cites W4233598183 @default.
• W4328116771 cites W4285495320 @default.
• W4328116771 cites W4289528728 @default.
• W4328116771 doi "https://doi.org/10.3389/fneur.2023.1142739" @default.
• W4328116771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37025197" @default.
• W4328116771 hasPublicationYear "2023" @default.
• W4328116771 type Work @default.
• W4328116771 citedByCount "0" @default.
• W4328116771 crossrefType "journal-article" @default.
• W4328116771 hasAuthorship W4328116771A5006250732 @default.
• W4328116771 hasAuthorship W4328116771A5010618113 @default.
• W4328116771 hasAuthorship W4328116771A5014068004 @default.
• W4328116771 hasAuthorship W4328116771A5022395038 @default.
• W4328116771 hasAuthorship W4328116771A5037677450 @default.
• W4328116771 hasAuthorship W4328116771A5040798172 @default.
• W4328116771 hasAuthorship W4328116771A5061360600 @default.
• W4328116771 hasAuthorship W4328116771A5062280178 @default.
• W4328116771 hasAuthorship W4328116771A5080631054 @default.
• W4328116771 hasBestOaLocation W43281167711 @default.
• W4328116771 hasConcept C142724271 @default.
• W4328116771 hasConcept C169760540 @default.
• W4328116771 hasConcept C172497186 @default.
• W4328116771 hasConcept C185592680 @default.
• W4328116771 hasConcept C203014093 @default.
• W4328116771 hasConcept C2776914184 @default.
• W4328116771 hasConcept C2779830541 @default.
• W4328116771 hasConcept C2781453256 @default.
• W4328116771 hasConcept C42219234 @default.
• W4328116771 hasConcept C529278444 @default.
• W4328116771 hasConcept C71924100 @default.
• W4328116771 hasConcept C86803240 @default.

• next