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- W4328118009 abstract "associated stromal cells starts at the stages of tumor formation and continues during growth, invasion, intravasation and establishment at the secondary site called metastasis. This cross-talk between the cancer cells with stromal cells becomes established a tumor microenvironment (TME). TME dynamically regulates cancer progression and promotes immune evasion and influences the therapeutic outcome. Hence, strategies to therapeutically target the TME have emerged as a promising approach for standard-of-care therapies. The TME comprises the extracellular matrix (ECM), secreted molecules (growth factors, cytokines, chemokines, and LGMN is reported in several cancers including breast, prostate, and liver cancers and in the macrophages of the tumor microenvironment. Hence, LGMN is considered a key protein involved in the regulation of tumor angiogenesis, invasion, and metastasis. Recent studies reported that targeting LGMN using siRNA or small molecular inhibitors was reported to reduce cancer cell growth in vitro and shrink tumor size in vivo. Furthermore, legumain can also be used as a diagnostic marker due to its expression being significantly lower in normal cells compared to tumors or tumor-associated macrophages (TAMs). Since LGMN plays an important role in the immune system and is preferentially over-expressed in tumor microenvironments and tumor tissues, targeting LGMN may be a promising strategy for tumor immunotherapy." @default.
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- W4328118009 date "2023-03-21" @default.
- W4328118009 modified "2023-10-01" @default.
- W4328118009 title "Editorial: Molecular targeting of the tumor microenvironment for therapeutics in cancer metastasis" @default.
- W4328118009 doi "https://doi.org/10.3389/fmolb.2023.1178488" @default.
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