FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328118725> ?p ?o ?g. }

• W4328118725 abstract "Astaxanthin is a dark red keto-carotenoid found in aquatic animals such as salmon and shrimp, and algae (Haematococcus pluvialis). Astaxanthin has a unique molecular structure that may facilitate anti-oxidative, immunomodulatory, and anti-inflammatory effects during physiological stress. The primary objective of this study was to examine the efficacy of 4-week ingestion of astaxanthin in moderating exercise-induced inflammation and immune dysfunction using a multi-omics approach.This study employed a randomized, double blind, placebo controlled, crossover design with two 4-week supplementation periods and a 2-week washout period. Study participants were randomized to astaxanthin and placebo trials, with supplements ingested daily for 4 weeks prior to running 2.25 h at close to 70%VO2max (including 30 min of 10% downhill running). After the washout period, participants repeated all procedures using the counterbalanced supplement. The astaxanthin capsule contained 8 mg of algae astaxanthin. Six blood samples were collected before and after supplementation (overnight fasted state), immediately post-exercise, and at 1.5, 3, and 24 h-post-exercise. Plasma aliquots were assayed using untargeted proteomics, and targeted oxylipin and cytokine panels.The 2.25 h running bout induced significant muscle soreness, muscle damage, and inflammation. Astaxanthin supplementation had no effect on exercise-induced muscle soreness, muscle damage, and increases in six plasma cytokines and 42 oxylipins. Notably, astaxanthin supplementation countered exercise-induced decreases in 82 plasma proteins (during 24 h recovery). Biological process analysis revealed that most of these proteins were involved in immune-related functions such as defense responses, complement activation, and humoral immune system responses. Twenty plasma immunoglobulins were identified that differed significantly between the astaxanthin and placebo trials. Plasma levels of IgM decreased significantly post-exercise but recovered after the 24 h post-exercise recovery period in the astaxanthin but not the placebo trial.These data support that 4-week astaxanthin versus placebo supplementation did not counter exercise-induced increases in plasma cytokines and oxylipins but was linked to normalization of post-exercise plasma levels of numerous immune-related proteins including immunoglobulins within 24 h. Short-term astaxanthin supplementation (8 mg/day during a 4-week period) provided immune support for runners engaging in a vigorous 2.25 h running bout and uniquely countered decreases in plasma immunoglobulin levels." @default.
• W4328118725 created "2023-03-22" @default.
• W4328118725 creator A5003122342 @default.
• W4328118725 creator A5007769559 @default.
• W4328118725 creator A5011015292 @default.
• W4328118725 creator A5013541518 @default.
• W4328118725 creator A5029455714 @default.
• W4328118725 creator A5034319272 @default.
• W4328118725 creator A5039723064 @default.
• W4328118725 creator A5070928221 @default.
• W4328118725 creator A5072521526 @default.
• W4328118725 date "2023-03-21" @default.
• W4328118725 modified "2023-10-14" @default.
• W4328118725 title "Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins" @default.
• W4328118725 cites W1507035827 @default.
• W4328118725 cites W154587595 @default.
• W4328118725 cites W1955470321 @default.
• W4328118725 cites W1978837338 @default.
• W4328118725 cites W1981049957 @default.
• W4328118725 cites W1984235919 @default.
• W4328118725 cites W1985491852 @default.
• W4328118725 cites W2005067517 @default.
• W4328118725 cites W2020196152 @default.
• W4328118725 cites W2039027645 @default.
• W4328118725 cites W2054432555 @default.
• W4328118725 cites W2085328948 @default.
• W4328118725 cites W2148283536 @default.
• W4328118725 cites W2158856757 @default.
• W4328118725 cites W2299406423 @default.
• W4328118725 cites W2405862462 @default.
• W4328118725 cites W2602477620 @default.
• W4328118725 cites W2606714207 @default.
• W4328118725 cites W2788680201 @default.
• W4328118725 cites W2793662128 @default.
• W4328118725 cites W2888926634 @default.
• W4328118725 cites W2900183821 @default.
• W4328118725 cites W2910780614 @default.
• W4328118725 cites W2921508866 @default.
• W4328118725 cites W2969190370 @default.
• W4328118725 cites W2991106430 @default.
• W4328118725 cites W3009193868 @default.
• W4328118725 cites W3028477478 @default.
• W4328118725 cites W3037898699 @default.
• W4328118725 cites W3040787474 @default.
• W4328118725 cites W3087570067 @default.
• W4328118725 cites W3096559557 @default.
• W4328118725 cites W3100448104 @default.
• W4328118725 cites W3181828173 @default.
• W4328118725 cites W3204300536 @default.
• W4328118725 cites W4200152981 @default.
• W4328118725 cites W4200193126 @default.
• W4328118725 cites W4206278084 @default.
• W4328118725 doi "https://doi.org/10.3389/fnut.2023.1143385" @default.
• W4328118725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37025615" @default.
• W4328118725 hasPublicationYear "2023" @default.
• W4328118725 type Work @default.
• W4328118725 citedByCount "2" @default.
• W4328118725 countsByYear W43281187252023 @default.
• W4328118725 crossrefType "journal-article" @default.
• W4328118725 hasAuthorship W4328118725A5003122342 @default.
• W4328118725 hasAuthorship W4328118725A5007769559 @default.
• W4328118725 hasAuthorship W4328118725A5011015292 @default.
• W4328118725 hasAuthorship W4328118725A5013541518 @default.
• W4328118725 hasAuthorship W4328118725A5029455714 @default.
• W4328118725 hasAuthorship W4328118725A5034319272 @default.
• W4328118725 hasAuthorship W4328118725A5039723064 @default.
• W4328118725 hasAuthorship W4328118725A5070928221 @default.
• W4328118725 hasAuthorship W4328118725A5072521526 @default.
• W4328118725 hasBestOaLocation W43281187251 @default.
• W4328118725 hasConcept C126322002 @default.
• W4328118725 hasConcept C134018914 @default.
• W4328118725 hasConcept C142724271 @default.
• W4328118725 hasConcept C146543888 @default.
• W4328118725 hasConcept C185592680 @default.
• W4328118725 hasConcept C193230392 @default.
• W4328118725 hasConcept C203014093 @default.
• W4328118725 hasConcept C204787440 @default.
• W4328118725 hasConcept C27081682 @default.
• W4328118725 hasConcept C2776151105 @default.
• W4328118725 hasConcept C2776914184 @default.
• W4328118725 hasConcept C2777399995 @default.
• W4328118725 hasConcept C2780962900 @default.
• W4328118725 hasConcept C28781525 @default.
• W4328118725 hasConcept C31903555 @default.
• W4328118725 hasConcept C71924100 @default.
• W4328118725 hasConcept C86803240 @default.
• W4328118725 hasConcept C87813604 @default.
• W4328118725 hasConcept C8891405 @default.
• W4328118725 hasConcept C98274493 @default.
• W4328118725 hasConceptScore W4328118725C126322002 @default.
• W4328118725 hasConceptScore W4328118725C134018914 @default.
• W4328118725 hasConceptScore W4328118725C142724271 @default.
• W4328118725 hasConceptScore W4328118725C146543888 @default.
• W4328118725 hasConceptScore W4328118725C185592680 @default.
• W4328118725 hasConceptScore W4328118725C193230392 @default.
• W4328118725 hasConceptScore W4328118725C203014093 @default.
• W4328118725 hasConceptScore W4328118725C204787440 @default.
• W4328118725 hasConceptScore W4328118725C27081682 @default.
• W4328118725 hasConceptScore W4328118725C2776151105 @default.
• W4328118725 hasConceptScore W4328118725C2776914184 @default.

• next