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- W4328121253 endingPage "2406" @default.
- W4328121253 startingPage "2406" @default.
- W4328121253 abstract "Retinal ischaemia is present to a greater or lesser extent in all eyes with diabetic retinopathy (DR). Nonetheless, our understanding of its pathogenic mechanisms, risk factors, as well as other characteristics of retinal ischaemia in DR is very limited. To date, there is no treatment to revascularise ischaemic retina.Review of the literature highlighting the current knowledge on the topic of retinal ischaemia in DR, important observations made, and underlying gaps for which research is needed.A very scarce number of clinical studies, mostly cross-sectional, have evaluated specifically retinal ischaemia in DR. Interindividual variability on its natural course and consequences, including the development of its major complications, namely diabetic macular ischaemia and proliferative diabetic retinopathy, have not been investigated. The in situ, surrounding, and distance effect of retinal ischaemia on retinal function and structure and its change over time remains also to be elucidated. Treatments to prevent the development of retinal ischaemia and, importantly, to achieve retinal reperfusion once capillary drop out has ensued, are very much needed and remain to be developed.Research into retinal ischaemia in diabetes should be a priority to save sight." @default.
- W4328121253 created "2023-03-22" @default.
- W4328121253 creator A5010098214 @default.
- W4328121253 creator A5013260117 @default.
- W4328121253 creator A5090676693 @default.
- W4328121253 creator A5091529501 @default.
- W4328121253 date "2023-03-21" @default.
- W4328121253 modified "2023-10-07" @default.
- W4328121253 title "Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge" @default.
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