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- W4328121254 abstract "The spawn of Lentinula edodes and other basidiomycete fungi tend to age with long-term culture. This causes heavy yield losses if aging spawn is used for propagation. In this study, we cultivated dikaryotic L. edodes mycelia in plates for 60 days to produce intrinsic aging phenotypes. We found that intracellular reactive oxygen species levels increased in contrast to mitochondrial depolarization and also observed greater DNA fragmentation with longer culture time. Transcriptome analysis of mycelia at different growth stages revealed pronounced expression differences between short- and long-term cultures. In particular, phenylalanine, tyrosine, and tryptophan biosynthesis, mitophagy and autophagy, MAPK signaling pathway, and ABC transporter were among the enriched terms in the mycelial aging process. Weighted correlation network analysis identified LeAtg8, LeHog1, LePbs2, and LemTOR as key genes during aging. Western blotting confirmed that LeATG8 and phosphorylated LeHOG1 protein levels were significantly upregulated in aging mycelia. Our combined analytical approach provides insights into the mechanisms that regulate mycelial aging, indicating that autophagy/mitophagy plays a major role in counteracting the effects of age on mycelial growth development." @default.
- W4328121254 created "2023-03-22" @default.
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- W4328121254 date "2023-03-20" @default.
- W4328121254 modified "2023-09-30" @default.
- W4328121254 title "Insights into the Global Transcriptome Response of Lentinula edodes Mycelia during Aging" @default.
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- W4328121254 doi "https://doi.org/10.3390/jof9030379" @default.
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