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- W4328123603 abstract "Abstract A couple of series of heterocyclic‐based urea and thiourea derivatives, connected with a hybrid scaffold skeleton containing pyrazole and piperazine ring moieties, were achieved. In this study, a total of fifteen new compounds were synthesized by reacting 1‐(3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐yl)piperazine hydrochloride with carbamides and thiocarbamides. All the fifteen newly synthesized compound structures were confirmed by 1 H & 13 C NMR and FTIR spectroscopy, ESI mass spectrometry, CHNS analysis and HPLC chromotograms. Moreover, the structures of N ‐allyl‐4‐(3‐methyl‐1‐phenyl‐ 1H ‐pyrazol‐5‐yl)piperazine‐1‐carbothioamide and 4‐(3‐methyl‐1‐phenyl‐ 1H ‐pyrazol‐5‐yl)‐ N ‐(4‐nitrophenyl)piperazine‐1‐carbothioamide were also confirmed by single‐crystal X‐ray diffraction analysis. Further, as per the objective of this work, all these fifteen newly synthesized compounds were screened for anti‐inflammatory activity. The majority of the compounds displayed moderate‐to‐good anti‐inflammatory activity. The anti‐inflammatory activity study was also correlated with molecular docking studies using the receptor Cyclooxygenase‐2." @default.
- W4328123603 created "2023-03-22" @default.
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- W4328123603 date "2023-03-21" @default.
- W4328123603 modified "2023-09-26" @default.
- W4328123603 title "Piperazine‐ and Pyrazole‐Based Heterocyclic Scaffold Derivatives Connected with Urea and Thiourea for Anti‐Inflammatory Activity" @default.
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- W4328123603 doi "https://doi.org/10.1002/slct.202300238" @default.
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