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- W4328124224 abstract "Abstract We previously observed sustained fMRI BOLD signal in the basal ganglia in focal hand dystonia patients after a repetitive finger tapping task. Since this was observed in a task-specific dystonia, for which excessive task repetition may play a role in pathogenesis, in the current study we asked if this effect would be observed in a focal dystonia (cervical dystonia [CD]) that is not considered task-specific or thought to result from overuse. We evaluated fMRI BOLD signal time courses before, during, and after the finger tapping task in CD patients. We observed patient/control differences in post-tapping BOLD signal in left putamen and left cerebellum during the non-dominant (left) hand tapping condition, reflecting abnormally sustained BOLD signal in CD. BOLD signals in left putamen and cerebellum were also abnormally elevated in CD during tapping itself and escalated as tapping was repeated. There were no cerebellar differences in the previously studied FHD cohort, either during or after tapping. We conclude that some elements of pathogenesis and/or pathophysiology associated with motor task execution/repetition may not be limited to task-specific dystonias, but there may be regional differences in these effects across dystonias, associated with different types of motor control programs." @default.
- W4328124224 created "2023-03-22" @default.
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- W4328124224 date "2023-03-21" @default.
- W4328124224 modified "2023-09-27" @default.
- W4328124224 title "Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia" @default.
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- W4328124224 doi "https://doi.org/10.1101/2023.03.19.533030" @default.
- W4328124224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36993354" @default.
- W4328124224 hasPublicationYear "2023" @default.