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- W4328124417 abstract "Abstract Memory encodes past experiences, thereby enabling future plans. The basolateral amygdala (BLA) is a center of salience networks that underlie emotional experience and thus plays a key role in long-term fear memory formation 1, 2 . Here we used spatial and single-cell transcriptomics to illuminate the cellular and molecular architecture of the role of the basolateral amygdala in long-term memory. We identified transcriptional signatures in subpopulations of neurons and astrocytes that were memory-specific and persisted for weeks. These transcriptional signatures implicate neuropeptide signaling, mitogen-activated protein kinase (MAPK), brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), ubiquitination pathways, and synaptic connectivity in long-term memory. We also discovered that a neuronal sub-population, defined by increased Penk expression and decreased Tac expression, constitutes the most prominent component of the BLA’s memory engram. These transcriptional changes were observed both with single-cell RNAseq and with single-molecule spatial transcriptomics in intact slices, thereby providing a rich spatial map of a memory engram. The spatial data enabled us to show that this neuronal subpopulation further interacts with spatially related astrocytes that are essential for memory consolidation, indicating that neurons require interactions with astrocytes to encode long term memory." @default.
- W4328124417 created "2023-03-22" @default.
- W4328124417 creator A5008020157 @default.
- W4328124417 creator A5013192823 @default.
- W4328124417 creator A5014254460 @default.
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- W4328124417 creator A5053097929 @default.
- W4328124417 creator A5061921730 @default.
- W4328124417 creator A5077757510 @default.
- W4328124417 creator A5090505297 @default.
- W4328124417 date "2023-03-21" @default.
- W4328124417 modified "2023-09-30" @default.
- W4328124417 title "Spatial and single-cell transcriptomics reveal neuron-astrocyte interplay in long-term memory" @default.
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