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- W4328124571 abstract "Acute stress response triggers various physiological responses such as energy mobilization to meet metabolic demands. However, the underlying molecular changes in the brain remain largely obscure. Here, we used a brief water avoidance stress (WAS) to elicit an acute stress response in mice. By employing RNA-sequencing and metabolomics profiling, we investigated the acute stress-induced molecular changes in the mouse whole brain. The aberrant expression of 60 genes was detected in the brain tissues of WAS-exposed mice. Functional analyses showed that the aberrantly expressed genes were enriched in various processes such as superoxide metabolism. In our global metabolomic profiling, a total of 43 brain metabolites were significantly altered by acute WAS. Metabolic pathways upregulated from WAS-exposed brain tissues relative to control samples included lipolysis, eicosanoid biosynthesis, and endocannabinoid synthesis. Acute WAS also elevated the levels of branched-chain amino acids, 5-aminovalerates, 4-hydroxy-nonenal-glutathione as well as mannose, suggesting complex metabolic changes in the brain. The observed molecular events in the present study provide a valuable resource that can help us better understand how acute psychological stress impacts neural functions." @default.
- W4328124571 created "2023-03-22" @default.
- W4328124571 creator A5017969706 @default.
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- W4328124571 date "2023-03-20" @default.
- W4328124571 modified "2023-10-14" @default.
- W4328124571 title "Metabolic and Transcriptomic Signatures of the Acute Psychological Stress Response in the Mouse Brain" @default.
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- W4328124571 doi "https://doi.org/10.3390/metabo13030453" @default.
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- W4328124571 hasPublicationYear "2023" @default.
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