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- W4328128251 abstract "Abstract Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological event that protects against various stimuli to maintain tissue homeostasis. However, the dysregulation of inflammatory responses can cause imbalance of the immune system, cell dysfunction and death. Recent studies have pointed out that activation of inflammation, including the activation of multiple inflammation-related signaling pathways, can lead to ferroptosis. Among the related signal transduction pathways, we focused on five classical inflammatory pathways, namely, the JAK-STAT, NF-κB, inflammasome, cGAS-STING and MAPK signaling pathways, and expounded on their roles in ferroptosis. To date, many agents have shown therapeutic effects on ferroptosis-related diseases by modulating the aforementioned pathways in vivo and in vitro. Moreover, the regulatory effects of these pathways on iron metabolism and lipid peroxidation have been described in detail, contributing to further understanding of the pathophysiological process of ferroptosis. Taken together, targeting these pathways related to inflammation will provide appropriate ways to intervene ferroptosis and diseases." @default.
- W4328128251 created "2023-03-22" @default.
- W4328128251 creator A5014801646 @default.
- W4328128251 creator A5035278117 @default.
- W4328128251 creator A5036521207 @default.
- W4328128251 creator A5081416018 @default.
- W4328128251 creator A5089718822 @default.
- W4328128251 date "2023-03-21" @default.
- W4328128251 modified "2023-10-09" @default.
- W4328128251 title "The interaction between ferroptosis and inflammatory signaling pathways" @default.
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