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• W4328128358 abstract "The present study aimed to investigate the dynamic changes in peripheral blood leucocyte subpopulations, cytokine and miRNA levels, and changes in computed tomography (CT) scores in patients with severe coronavirus disease 2019 (COVID‑19) (n=14) and age‑matched non‑COVID‑19 volunteers (n=17), which were included as a reference control group. All data were collected on the day of patient admission (day 0) and on the 7th, 14th and 28th days of follow‑up while CT of the lungs was performed on weeks 2, 8, 24 and 48. On day 0, lymphopenia and leucopenia were detected in most patients with COVID‑19, as well as an increase in the percentage of banded neutrophils, B cells, and CD4⁺ Treg cells, and a decrease in the content of PD‑1^low T cells, classical, plasmacytoid, and regulatory dendritic cells. On day 7, the percentage of T and natural killer cells decreased with a concurrent increase in B cells, but returned to the initial level after treatment discharge. The content of different T and dendritic cell subsets among CD45⁺ cells increased during two weeks and remained elevated, suggesting the activation of an adaptive immune response. The increase of PD‑1‑positive subpopulations of T and non‑T cells and regulatory CD4 T cells in patients with COVID‑19 during the observation period suggests the development of an inflammation control mechanism. The levels of interferon γ‑induced protein 10 (IP‑10), tumor necrosis factor‑α (TNF‑α) and interleukin (IL)‑6 decreased on day 7, but increased again on days 14 and 28. C‑reactive protein and granulocyte colony‑stimulating factor (G‑CSF) levels decreased gradually throughout the observation period. The relative expression levels of microRNA (miR)‑21‑5p, miR‑221‑3p, miR‑27a‑3p, miR‑146a‑5p, miR‑133a‑3p, and miR‑126‑3p were significantly higher at the beginning of hospitalization compared to non‑COVID‑19 volunteers. The plasma levels of all miRs, except for miR‑126‑3p, normalized within one week of treatment. At week 48, CT scores were most prominently correlated with the content of lymphocytes, senescent memory T cells, CD127⁺ T cells and CD57⁺ T cells, and increased concentrations of G‑CSF, IP‑10, and macrophage inflammatory protein‑1α." @default.
• W4328128358 created "2023-03-22" @default.
• W4328128358 creator A5001078831 @default.
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• W4328128358 date "2023-03-21" @default.
• W4328128358 modified "2023-10-16" @default.
• W4328128358 title "Dynamic changes in radiological parameters, immune cells, selected miRNAs, and cytokine levels in peripheral blood of patients with severe COVID‑19" @default.
• W4328128358 cites W1600560134 @default.
• W4328128358 cites W1977142289 @default.
• W4328128358 cites W2006303725 @default.
• W4328128358 cites W2017712207 @default.
• W4328128358 cites W2020753889 @default.
• W4328128358 cites W2021287992 @default.
• W4328128358 cites W2022267429 @default.
• W4328128358 cites W2042743674 @default.
• W4328128358 cites W2043283213 @default.
• W4328128358 cites W2051639636 @default.
• W4328128358 cites W2075860675 @default.
• W4328128358 cites W2080138182 @default.
• W4328128358 cites W2106398910 @default.
• W4328128358 cites W2107277218 @default.
• W4328128358 cites W2117683008 @default.
• W4328128358 cites W2192080449 @default.
• W4328128358 cites W2585745459 @default.
• W4328128358 cites W2594173948 @default.
• W4328128358 cites W2594830724 @default.
• W4328128358 cites W2617620062 @default.
• W4328128358 cites W2784247690 @default.
• W4328128358 cites W2897826048 @default.
• W4328128358 cites W2936400586 @default.
• W4328128358 cites W2940522848 @default.
• W4328128358 cites W2950072050 @default.
• W4328128358 cites W2966185882 @default.
• W4328128358 cites W3001118548 @default.
• W4328128358 cites W3007460166 @default.
• W4328128358 cites W3007670341 @default.
• W4328128358 cites W3007940623 @default.
• W4328128358 cites W3009859788 @default.
• W4328128358 cites W3009875419 @default.
• W4328128358 cites W3009951436 @default.
• W4328128358 cites W3011568661 @default.
• W4328128358 cites W3014003872 @default.
• W4328128358 cites W3015228903 @default.
• W4328128358 cites W3015410891 @default.
• W4328128358 cites W3015849236 @default.
• W4328128358 cites W3016508437 @default.
• W4328128358 cites W3016675451 @default.
• W4328128358 cites W3017944572 @default.
• W4328128358 cites W3018868982 @default.
• W4328128358 cites W3020023582 @default.
• W4328128358 cites W3024268458 @default.
• W4328128358 cites W3024643080 @default.
• W4328128358 cites W3024879069 @default.
• W4328128358 cites W3030478153 @default.
• W4328128358 cites W3032543466 @default.
• W4328128358 cites W3034684350 @default.
• W4328128358 cites W3039456903 @default.
• W4328128358 cites W3040110637 @default.
• W4328128358 cites W3041200191 @default.
• W4328128358 cites W3049243611 @default.
• W4328128358 cites W3081044306 @default.
• W4328128358 cites W3082438395 @default.
• W4328128358 cites W3082675822 @default.
• W4328128358 cites W3085935634 @default.
• W4328128358 cites W3088504623 @default.
• W4328128358 cites W3090358394 @default.
• W4328128358 cites W3092490718 @default.
• W4328128358 cites W3092856616 @default.
• W4328128358 cites W3093261446 @default.
• W4328128358 cites W3093410771 @default.
• W4328128358 cites W3096383810 @default.
• W4328128358 cites W3098862363 @default.
• W4328128358 cites W3103291132 @default.
• W4328128358 cites W3104394245 @default.
• W4328128358 cites W3105440841 @default.
• W4328128358 cites W3108071882 @default.
• W4328128358 cites W3114686513 @default.
• W4328128358 cites W3119419719 @default.
• W4328128358 cites W3119446940 @default.
• W4328128358 cites W3120742093 @default.
• W4328128358 cites W3121109439 @default.
• W4328128358 cites W3122085709 @default.
• W4328128358 cites W3123130740 @default.
• W4328128358 cites W3125501216 @default.
• W4328128358 cites W3131435205 @default.
• W4328128358 cites W3132811058 @default.
• W4328128358 cites W3135780457 @default.
• W4328128358 cites W3138545375 @default.
• W4328128358 cites W3152176761 @default.
• W4328128358 cites W3164181530 @default.

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