FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328129061> ?p ?o ?g. }

• W4328129061 abstract "Abstract Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs). This study focused on the role and mechanism of the p38 inhibitor TAK-715 in intervertebral disc degeneration. Methods NPCs were treated with IL-1β to mimic apoptosis, followed by the addition of TAK-715. It was determined that apoptosis, inflammatory mediators (COX-2), inflammatory cytokines (HMGB1), and ECM components (collagen II, MMP9, ADAMTS5, and MMP3) existed in NPCs. In addition, the p38MAPK signaling pathways were examined. The role of TAK-715 in vivo was determined by acupuncture-induced intervertebral disc degeneration. Following an intradiscal injection of TAK-715, MRI and a histopathological analysis were conducted to assess the degree of degeneration. Results IL-1β-induced apoptosis was alleviated by TAK-715 in vitro, and antiapoptotic proteins were upregulated. Furthermore, TAK-715 blocked IL-1β-induced inflammatory mediator production (COX-2) and inflammatory cytokine production (HMGB1) and degraded the ECM (collagen II, MMP9, ADAMTS5, and MMP3). By inhibiting the phosphorylation of p38, TAK-715 exerted its effects. In a rat tail model, TAK-715 ameliorates puncture-induced disc degeneration based on MRI and histopathology evaluations. Conclusion TAK-715 attenuated intervertebral disc degeneration in vitro and in vivo, suggesting that it might be an effective treatment for IDD." @default.
• W4328129061 created "2023-03-22" @default.
• W4328129061 creator A5009834995 @default.
• W4328129061 creator A5017583260 @default.
• W4328129061 creator A5021384155 @default.
• W4328129061 creator A5030691366 @default.
• W4328129061 creator A5036392167 @default.
• W4328129061 creator A5041038706 @default.
• W4328129061 creator A5046882360 @default.
• W4328129061 creator A5049078993 @default.
• W4328129061 creator A5058378813 @default.
• W4328129061 creator A5059551005 @default.
• W4328129061 creator A5063249708 @default.
• W4328129061 creator A5076952277 @default.
• W4328129061 creator A5088327986 @default.
• W4328129061 date "2023-03-21" @default.
• W4328129061 modified "2023-10-18" @default.
• W4328129061 title "TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo" @default.
• W4328129061 cites W1919987938 @default.
• W4328129061 cites W1966188170 @default.
• W4328129061 cites W1990910525 @default.
• W4328129061 cites W1993704673 @default.
• W4328129061 cites W1996785852 @default.
• W4328129061 cites W2009537114 @default.
• W4328129061 cites W2024585159 @default.
• W4328129061 cites W2038841465 @default.
• W4328129061 cites W2042464158 @default.
• W4328129061 cites W2045156352 @default.
• W4328129061 cites W2045770273 @default.
• W4328129061 cites W2059483506 @default.
• W4328129061 cites W2069792106 @default.
• W4328129061 cites W2079588007 @default.
• W4328129061 cites W2092798278 @default.
• W4328129061 cites W2093098656 @default.
• W4328129061 cites W2104082092 @default.
• W4328129061 cites W2123487526 @default.
• W4328129061 cites W2149650813 @default.
• W4328129061 cites W2162182198 @default.
• W4328129061 cites W2166016039 @default.
• W4328129061 cites W2281598305 @default.
• W4328129061 cites W2314974940 @default.
• W4328129061 cites W2417056655 @default.
• W4328129061 cites W2498261023 @default.
• W4328129061 cites W2505773930 @default.
• W4328129061 cites W2543904698 @default.
• W4328129061 cites W2586310998 @default.
• W4328129061 cites W2609830904 @default.
• W4328129061 cites W2790410554 @default.
• W4328129061 cites W2901270382 @default.
• W4328129061 cites W2912654919 @default.
• W4328129061 cites W2916745611 @default.
• W4328129061 cites W2965282693 @default.
• W4328129061 cites W2976859187 @default.
• W4328129061 cites W2997851069 @default.
• W4328129061 cites W3037545284 @default.
• W4328129061 cites W3092488480 @default.
• W4328129061 cites W3098533374 @default.
• W4328129061 cites W3165716369 @default.
• W4328129061 cites W319435296 @default.
• W4328129061 cites W3200477859 @default.
• W4328129061 cites W4220665724 @default.
• W4328129061 doi "https://doi.org/10.1186/s13075-023-03028-4" @default.
• W4328129061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36945021" @default.
• W4328129061 hasPublicationYear "2023" @default.
• W4328129061 type Work @default.
• W4328129061 citedByCount "1" @default.
• W4328129061 countsByYear W43281290612023 @default.
• W4328129061 crossrefType "journal-article" @default.
• W4328129061 hasAuthorship W4328129061A5009834995 @default.
• W4328129061 hasAuthorship W4328129061A5017583260 @default.
• W4328129061 hasAuthorship W4328129061A5021384155 @default.
• W4328129061 hasAuthorship W4328129061A5030691366 @default.
• W4328129061 hasAuthorship W4328129061A5036392167 @default.
• W4328129061 hasAuthorship W4328129061A5041038706 @default.
• W4328129061 hasAuthorship W4328129061A5046882360 @default.
• W4328129061 hasAuthorship W4328129061A5049078993 @default.
• W4328129061 hasAuthorship W4328129061A5058378813 @default.
• W4328129061 hasAuthorship W4328129061A5059551005 @default.
• W4328129061 hasAuthorship W4328129061A5063249708 @default.
• W4328129061 hasAuthorship W4328129061A5076952277 @default.
• W4328129061 hasAuthorship W4328129061A5088327986 @default.
• W4328129061 hasBestOaLocation W43281290611 @default.
• W4328129061 hasConcept C104317684 @default.
• W4328129061 hasConcept C105702510 @default.
• W4328129061 hasConcept C109523444 @default.
• W4328129061 hasConcept C126322002 @default.
• W4328129061 hasConcept C142724271 @default.
• W4328129061 hasConcept C150194340 @default.
• W4328129061 hasConcept C150903083 @default.
• W4328129061 hasConcept C185592680 @default.
• W4328129061 hasConcept C190283241 @default.
• W4328129061 hasConcept C203014093 @default.
• W4328129061 hasConcept C207001950 @default.
• W4328129061 hasConcept C2776914184 @default.
• W4328129061 hasConcept C2777755357 @default.
• W4328129061 hasConcept C2779295440 @default.
• W4328129061 hasConcept C2779354088 @default.
• W4328129061 hasConcept C502942594 @default.
• W4328129061 hasConcept C51551487 @default.
• W4328129061 hasConcept C55493867 @default.

• next