Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328129331> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4328129331 abstract "Mastitis, an infection of the mammary glands, is a common livestock disease. The bacterium Staphylococcus aureus is the principal cause of mastitis. Bovine mastitis results in large economic losses for farmers and the dairy industry due to decreased milk production, veterinary treatment costs, early livestock culling and preventive measures. Importantly, mastitis can pose a risk to public health due to the potential ingestion of bacterial toxins by consumers, residual antibiotics used to treat cows, and transmission of S. aureus among livestock and humans. Frequent interspecies transmissions between livestock and farmers underscore this view. The subsequent bacterial adaptations to a new host are facilitated by the horizontal transfer of mobile genetic elements (MGEs) carrying genes for virulence, immune evasion and antimicrobial resistance. Effective vaccines are highly desirable to fight bovine mastitis, but they do not yet exist. Since proteins exposed on the bacterial cell surface are attractive targets for immunization approaches, the research documented in this PhD thesis identified candidate vaccine targets through an integrated genomics, immunoproteomics and immunological approach. Special attention was attributed to S. aureus isolates from Mexican cows with mastitis, where potential vaccine targets and the role of MGEs in antibiotic resistance and virulence were investigated. The results show that particular exposed domains of proteins from the bacterial cell surface are attractive candidates for inclusion in a vaccine against bovine mastitis. Altogether, the research presented in this thesis shows that combined proteo-genomic and immunological analyses provide relevant leads for developing future subunit vaccines against staphylococcal infections in livestock." @default.
- W4328129331 created "2023-03-22" @default.
- W4328129331 creator A5030383393 @default.
- W4328129331 date "2023-03-21" @default.
- W4328129331 modified "2023-10-17" @default.
- W4328129331 title "Identification of potential vaccine targets in livestock-associated Staphylococcus aureus" @default.
- W4328129331 doi "https://doi.org/10.33612/diss.603997933" @default.
- W4328129331 hasPublicationYear "2023" @default.
- W4328129331 type Work @default.
- W4328129331 citedByCount "0" @default.
- W4328129331 crossrefType "dissertation" @default.
- W4328129331 hasAuthorship W4328129331A5030383393 @default.
- W4328129331 hasBestOaLocation W43281293311 @default.
- W4328129331 hasConcept C104317684 @default.
- W4328129331 hasConcept C112964050 @default.
- W4328129331 hasConcept C140793950 @default.
- W4328129331 hasConcept C150903083 @default.
- W4328129331 hasConcept C18903297 @default.
- W4328129331 hasConcept C194775826 @default.
- W4328129331 hasConcept C203014093 @default.
- W4328129331 hasConcept C2776344049 @default.
- W4328129331 hasConcept C2779489039 @default.
- W4328129331 hasConcept C501593827 @default.
- W4328129331 hasConcept C523546767 @default.
- W4328129331 hasConcept C52991690 @default.
- W4328129331 hasConcept C54355233 @default.
- W4328129331 hasConcept C60987743 @default.
- W4328129331 hasConcept C86803240 @default.
- W4328129331 hasConcept C89423630 @default.
- W4328129331 hasConcept C94665300 @default.
- W4328129331 hasConceptScore W4328129331C104317684 @default.
- W4328129331 hasConceptScore W4328129331C112964050 @default.
- W4328129331 hasConceptScore W4328129331C140793950 @default.
- W4328129331 hasConceptScore W4328129331C150903083 @default.
- W4328129331 hasConceptScore W4328129331C18903297 @default.
- W4328129331 hasConceptScore W4328129331C194775826 @default.
- W4328129331 hasConceptScore W4328129331C203014093 @default.
- W4328129331 hasConceptScore W4328129331C2776344049 @default.
- W4328129331 hasConceptScore W4328129331C2779489039 @default.
- W4328129331 hasConceptScore W4328129331C501593827 @default.
- W4328129331 hasConceptScore W4328129331C523546767 @default.
- W4328129331 hasConceptScore W4328129331C52991690 @default.
- W4328129331 hasConceptScore W4328129331C54355233 @default.
- W4328129331 hasConceptScore W4328129331C60987743 @default.
- W4328129331 hasConceptScore W4328129331C86803240 @default.
- W4328129331 hasConceptScore W4328129331C89423630 @default.
- W4328129331 hasConceptScore W4328129331C94665300 @default.
- W4328129331 hasLocation W43281293311 @default.
- W4328129331 hasLocation W432812933110 @default.
- W4328129331 hasLocation W432812933111 @default.
- W4328129331 hasLocation W432812933112 @default.
- W4328129331 hasLocation W43281293312 @default.
- W4328129331 hasLocation W43281293313 @default.
- W4328129331 hasLocation W43281293314 @default.
- W4328129331 hasLocation W43281293315 @default.
- W4328129331 hasLocation W43281293316 @default.
- W4328129331 hasLocation W43281293317 @default.
- W4328129331 hasLocation W43281293318 @default.
- W4328129331 hasLocation W43281293319 @default.
- W4328129331 hasOpenAccess W4328129331 @default.
- W4328129331 hasPrimaryLocation W43281293311 @default.
- W4328129331 hasRelatedWork W1977571916 @default.
- W4328129331 hasRelatedWork W1979586150 @default.
- W4328129331 hasRelatedWork W1996409898 @default.
- W4328129331 hasRelatedWork W2042590317 @default.
- W4328129331 hasRelatedWork W2075989176 @default.
- W4328129331 hasRelatedWork W2471180173 @default.
- W4328129331 hasRelatedWork W2805184262 @default.
- W4328129331 hasRelatedWork W3125557516 @default.
- W4328129331 hasRelatedWork W4229367358 @default.
- W4328129331 hasRelatedWork W4315647785 @default.
- W4328129331 isParatext "false" @default.
- W4328129331 isRetracted "false" @default.
- W4328129331 workType "dissertation" @default.