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- W4328129788 endingPage "571" @default.
- W4328129788 startingPage "571" @default.
- W4328129788 abstract "Stroke causes varying degrees of neurological deficits, leading to corresponding dysfunctions. There are different therapeutic principles for each stage of pathological development. Neuroprotection is the main treatment in the acute phase, and functional recovery becomes primary in the subacute and chronic phases. Neuroplasticity is considered the basis of functional restoration and neurological rehabilitation after stroke, including the remodeling of dendrites and dendritic spines, axonal sprouting, myelin regeneration, synapse shaping, and neurogenesis. Spatiotemporal development affects the spontaneous rewiring of neural circuits and brain networks. Microglia are resident immune cells in the brain that contribute to homeostasis under physiological conditions. Microglia are activated immediately after stroke, and phenotypic polarization changes and phagocytic function are crucial for regulating focal and global brain inflammation and neurological recovery. We have previously shown that the development of neuroplasticity is spatiotemporally consistent with microglial activation, suggesting that microglia may have a profound impact on neuroplasticity after stroke and may be a key therapeutic target for post-stroke rehabilitation. In this review, we explore the impact of neuroplasticity on post-stroke restoration as well as the functions and mechanisms of microglial activation, polarization, and phagocytosis. This is followed by a summary of microglia-targeted rehabilitative interventions that influence neuroplasticity and promote stroke recovery." @default.
- W4328129788 created "2023-03-22" @default.
- W4328129788 creator A5008313963 @default.
- W4328129788 creator A5026554334 @default.
- W4328129788 creator A5073084774 @default.
- W4328129788 date "2023-03-21" @default.
- W4328129788 modified "2023-10-14" @default.
- W4328129788 title "The Implications of Microglial Regulation in Neuroplasticity-Dependent Stroke Recovery" @default.
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