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- W4328129849 endingPage "969" @default.
- W4328129849 startingPage "969" @default.
- W4328129849 abstract "Cancer is a societal burden demanding innovative approaches. A major problem with the conventional chemotherapeutic agents is their strong toxicity and other side effects due to their poor selectivity. Uncontrolled proliferation of cancer cells is due to mutations, deletions, or amplifications in genes (oncogenes) encoding for proteins that regulate cell growth and division, such as transcription factors, for example, c-MYC. The direct targeting of the c-MYC protein has been attempted but so far unsuccessfully, as it lacks a definite binding site for the modulators. Meanwhile, another approach has been explored since the discovery that G-quadruplex secondary DNA structures formed in the guanine-rich sequences of the c-MYC promoter region can downregulate the transcription of this oncogene. Here, we will overview the major achievements made in the last decades towards the discovery of a new class of anticancer drugs targeting G-quadruplexes in the c-MYC promoter of cancer cells." @default.
- W4328129849 created "2023-03-22" @default.
- W4328129849 creator A5006715539 @default.
- W4328129849 creator A5047338844 @default.
- W4328129849 creator A5052629340 @default.
- W4328129849 creator A5059313807 @default.
- W4328129849 creator A5071711840 @default.
- W4328129849 date "2023-03-21" @default.
- W4328129849 modified "2023-10-18" @default.
- W4328129849 title "G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy" @default.
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