FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328130252> ?p ?o ?g. }

• W4328130252 abstract "Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has a complex tumor immune microenvironment (TIME), the clinical value of which remains elusive. This study aimed to delineate the immune landscape of PDAC and determine the clinical value of immune features in TIME. Methods Univariable and multivariable Cox regression analyses were performed to evaluate the clinical value of immune features and establish a new prognostic model. We also conducted single-cell RNA sequencing (scRNA-seq) to further characterize the immune profiles of PDAC and explore cell-to-cell interactions. Results There was a significant difference in the immune profiles between PDAC and adjacent noncancerous tissues. Several novel immune features were captured by quantitative pathological analysis on multiplex immunohistochemistry (mIHC), some of which were significantly correlated with the prognosis of patients with PDAC. A risk score-based prognostic model was established based on these immune features. We also constructed a user-friendly nomogram plot to predict the overall survival (OS) of patients by combining the risk score and clinicopathological features. Both mIHC and scRNA-seq analysis revealed PD-L1 expression was low in PDAC. We found that PD1 + cells were distributed in different T cell subpopulations, and were not enriched in a specific subpopulation. In addition, there were other conserved receptor-ligand pairs (CCL5-SDC1/4) besides the PD1-PD-L1 interaction between PD1 + T cells and PD-L1 + tumor cells. Conclusion Our findings reveal the immune landscape of PDAC and highlight the significant value of the combined application of mIHC and scRNA-seq for uncovering TIME, which might provide new clues for developing immunotherapy combination strategies." @default.
• W4328130252 created "2023-03-22" @default.
• W4328130252 creator A5004905094 @default.
• W4328130252 creator A5015195367 @default.
• W4328130252 creator A5038097386 @default.
• W4328130252 creator A5051841011 @default.
• W4328130252 creator A5074339191 @default.
• W4328130252 creator A5080290903 @default.
• W4328130252 date "2023-03-21" @default.
• W4328130252 modified "2023-10-16" @default.
• W4328130252 title "Immune profiling and prognostic model of pancreatic cancer using quantitative pathology and single-cell RNA sequencing" @default.
• W4328130252 cites W1815157104 @default.
• W4328130252 cites W2097995306 @default.
• W4328130252 cites W2118982164 @default.
• W4328130252 cites W2136859769 @default.
• W4328130252 cites W2282664279 @default.
• W4328130252 cites W2560367415 @default.
• W4328130252 cites W2580601893 @default.
• W4328130252 cites W2739132742 @default.
• W4328130252 cites W2750317630 @default.
• W4328130252 cites W2789892285 @default.
• W4328130252 cites W2901903079 @default.
• W4328130252 cites W2925446385 @default.
• W4328130252 cites W2951890476 @default.
• W4328130252 cites W2954610188 @default.
• W4328130252 cites W2981790403 @default.
• W4328130252 cites W2982130750 @default.
• W4328130252 cites W2988644538 @default.
• W4328130252 cites W3016937331 @default.
• W4328130252 cites W3017374234 @default.
• W4328130252 cites W3019427476 @default.
• W4328130252 cites W3023906975 @default.
• W4328130252 cites W3087232085 @default.
• W4328130252 cites W3110528877 @default.
• W4328130252 cites W3128991856 @default.
• W4328130252 cites W3147787140 @default.
• W4328130252 cites W3166338252 @default.
• W4328130252 cites W3197559541 @default.
• W4328130252 cites W3201147040 @default.
• W4328130252 cites W3205475594 @default.
• W4328130252 cites W4206841660 @default.
• W4328130252 cites W4225371778 @default.
• W4328130252 doi "https://doi.org/10.1186/s12967-023-04051-4" @default.
• W4328130252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36944944" @default.
• W4328130252 hasPublicationYear "2023" @default.
• W4328130252 type Work @default.
• W4328130252 citedByCount "3" @default.
• W4328130252 countsByYear W43281302522023 @default.
• W4328130252 crossrefType "journal-article" @default.
• W4328130252 hasAuthorship W4328130252A5004905094 @default.
• W4328130252 hasAuthorship W4328130252A5015195367 @default.
• W4328130252 hasAuthorship W4328130252A5038097386 @default.
• W4328130252 hasAuthorship W4328130252A5051841011 @default.
• W4328130252 hasAuthorship W4328130252A5074339191 @default.
• W4328130252 hasAuthorship W4328130252A5080290903 @default.
• W4328130252 hasBestOaLocation W43281302521 @default.
• W4328130252 hasConcept C142724271 @default.
• W4328130252 hasConcept C143998085 @default.
• W4328130252 hasConcept C203014093 @default.
• W4328130252 hasConcept C204232928 @default.
• W4328130252 hasConcept C207886595 @default.
• W4328130252 hasConcept C2776107976 @default.
• W4328130252 hasConcept C34626388 @default.
• W4328130252 hasConcept C502942594 @default.
• W4328130252 hasConcept C71924100 @default.
• W4328130252 hasConcept C86803240 @default.
• W4328130252 hasConcept C8891405 @default.
• W4328130252 hasConceptScore W4328130252C142724271 @default.
• W4328130252 hasConceptScore W4328130252C143998085 @default.
• W4328130252 hasConceptScore W4328130252C203014093 @default.
• W4328130252 hasConceptScore W4328130252C204232928 @default.
• W4328130252 hasConceptScore W4328130252C207886595 @default.
• W4328130252 hasConceptScore W4328130252C2776107976 @default.
• W4328130252 hasConceptScore W4328130252C34626388 @default.
• W4328130252 hasConceptScore W4328130252C502942594 @default.
• W4328130252 hasConceptScore W4328130252C71924100 @default.
• W4328130252 hasConceptScore W4328130252C86803240 @default.
• W4328130252 hasConceptScore W4328130252C8891405 @default.
• W4328130252 hasFunder F4320321001 @default.
• W4328130252 hasIssue "1" @default.
• W4328130252 hasLocation W43281302521 @default.
• W4328130252 hasLocation W43281302522 @default.
• W4328130252 hasLocation W43281302523 @default.
• W4328130252 hasOpenAccess W4328130252 @default.
• W4328130252 hasPrimaryLocation W43281302521 @default.
• W4328130252 hasRelatedWork W2052370293 @default.
• W4328130252 hasRelatedWork W2120603712 @default.
• W4328130252 hasRelatedWork W2168316764 @default.
• W4328130252 hasRelatedWork W2317562038 @default.
• W4328130252 hasRelatedWork W2371465821 @default.
• W4328130252 hasRelatedWork W2389169808 @default.
• W4328130252 hasRelatedWork W2585905148 @default.
• W4328130252 hasRelatedWork W2965180945 @default.
• W4328130252 hasRelatedWork W3030649553 @default.
• W4328130252 hasRelatedWork W4385545535 @default.
• W4328130252 hasVolume "21" @default.
• W4328130252 isParatext "false" @default.
• W4328130252 isRetracted "false" @default.
• W4328130252 workType "article" @default.