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- W4328130293 abstract "Abstract Introduction : Probiotic supplementations have become a recent area of interest among the many treatment options for necrotizing enterocolitis (NEC). Therefore, the systematic review sought to answer the question; in very low birth weight infants (VLBW), how can probiotic supplementation reduce necrotizing enterocolitis? Methodology : This is a systematic analysis conducted using trials obtained from PubMed, EMBASE, and Cochrane Library. Randomized trials from the last decade were considered for inclusion in the study. A literal, systematic analysis of the included studies was performed to investigate outcomes such as feeding tolerance and resumption to full enteral feeding, weight gain, length of hospitalization, and increase in gut colonization and microbiota count. Results : A total of 10 studies investigating 2480 VLBW infant participants were randomized as follows; 1217 VLBW infants receiving probiotics and 1263 VLBW infants as control. Four outcome measures were used to indicate a reduction of NEC in the patients; feeding tolerance and resumption to full enteral feeding, weight gain, length of hospitalization, and increase in gut colonization and microbiota count. Each outcome was significantly positive in favour of supplemental probiotics. Conclusions : There is evidence from a systematic analysis of 10 studies that supplementing the feeds of VLBW infants with probiotics increases their chances of surviving NEC. In the future, randomized trials should concentrate on elucidating this niche by conducting direct comparisons of probiotics to determine the most effective among the available." @default.
- W4328130293 created "2023-03-22" @default.
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- W4328130293 date "2023-03-21" @default.
- W4328130293 modified "2023-10-17" @default.
- W4328130293 title "Probiotics Supplementation in Reduction of Necrotizing Enterocolitis in Very Low Birth Weight Infants" @default.
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- W4328130293 doi "https://doi.org/10.21203/rs.3.rs-2682002/v1" @default.
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