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• W4328130694 abstract "Abstract Background Hepatic liver disease, including primary sclerosing cholangitis (PSC), is a serious extraintestinal manifestations of colonic inflammation. Cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CrebH) is a transcription factor expressed mostly in the liver and small intestine. However, CrebH’s roles in the gut–liver axis remain unknown. Methods Inflammatory bowel disease (IBD) and PSC disease models were established in wild-type and CrebH -/- mice treated with dextran sulfate sodium, dinitrobenzene sulfonic acid, and diethoxycarbonyl dihydrocollidine diet, respectively. RNA sequencing were conducted to investigate differential gene expression. Exosomes were isolated from plasma and culture media. miRNA expression profiling was performed using the NanoString nCounter Mouse miRNA Panel. Effects of miR-29a-3p on adhesion molecule expression were investigated in bEnd.3 brain endothelial cells. Results CrebH -/- mice exhibited accelerated liver injury without substantial differences in the gut after administration of dextran sulfate sodium (DSS), and had similar features to PSC, including enlarged bile ducts, enhanced inflammation, and aberrant MAdCAM-1 expression. Furthermore, RNA-sequencing analysis showed that differentially expressed genes in the liver of CrebH -/- mice after DSS overlapped significantly with genes changed in PSC-liver. Analysis of plasma exosome miRNA isolated from WT and CrebH -/- mice indicates that CrebH can contribute to the exosomal miRNA profile. We also identified miR-29a-3p as an effective mediator for MAdCAM-1 expression. Administration of plasma exosome from CrebH -/- mice led to prominent inflammatory signals in the liver of WT mice with inflammatory bowel disease (IBD). Conclusions CrebH deficiency led to increased susceptibility to IBD-induced liver diseases via enhanced expression of adhesion molecules and concomitant infiltration of T lymphocytes. Exosomes can contribute to the progression of IBD-induced liver injury in CrebH -/- mice. These study provide novel insights into the role of CrebH in IBD-induced liver injury." @default.
• W4328130694 created "2023-03-22" @default.
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• W4328130694 date "2023-03-21" @default.
• W4328130694 modified "2023-10-16" @default.
• W4328130694 title "CrebH protects against liver injury associated with colonic inflammation via modulation of exosomal miRNA" @default.
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• W4328130694 doi "https://doi.org/10.21203/rs.3.rs-2636684/v1" @default.
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