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- W4328130868 abstract "Abstract Objectives To assess the independent causal effect of body mass index (BMI) and 25-hydroxy-vitamin D (25(OH)D) level on basal cell carcinoma(BCC), we performed univariable and multivariable two-sample Mendelian randomization (MR) analysis. Methods We used overlapping genome-wide significant single nucleotide polymorphisms(SNPs) for BMI and 25(OH)D as instrumental variables and selected effective SNPs to applied a series of MR methods including inverse variance weighted (IVW),MR Egger,and Weighted median. After that, we employed sensitivity analysis to make sure the results were reliable and robust. Results In the univariable two-sample MR analysis, higher BMI was related to lower risk for BCC (Odds ratio(OR)=0.90; 95%confidence interval (CI),[0.81,0.99]; p = 0.02). In the multivariable MR, the causal effect of BMI on BCC after adjusting for 25(OH)D level still remained(OR=0.88; 95% CI,[−0.22; −0.03], p-value=0.008).However,our results suggest that 25(OH)D level was not associated with BCC(OR=1.02; 95%CI,[0.94,1.09],p-value=0.67). Conclusion Similar to the conclusions of previous observational studies, the MR results suggest that BMI is an independent protective factor for BCC. While, vitamin D levels may not be causally associated with the risk of basal cell carcinoma and increasing vitamin D supplementation is unlikely to reduce the risk." @default.
- W4328130868 created "2023-03-22" @default.
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- W4328130868 date "2023-03-21" @default.
- W4328130868 modified "2023-10-10" @default.
- W4328130868 title "Evaluating the effect of body mass index and 25-hydroxy-vitamin D level on basal cell carcinoma: a Mendelian randomization research" @default.
- W4328130868 doi "https://doi.org/10.21203/rs.3.rs-2679716/v1" @default.
- W4328130868 hasPublicationYear "2023" @default.
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