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- W4328131341 abstract "Abstract Natural polysaccharide is a type of functional carbohydrate polymer under heated investigation. The structure of natural polysaccharides is in close relationship with their actual biological functions such as antioxidant, immunoregulation and antitumor effects. Herein, we have identified numerous factors that significantly affect the biological functions of polysaccharides, including molecular weight, degree of polymerization, hydrophilicity and metabolic capability. Mitochondria, as a key polysaccharide-targeting organelle, undergo a number of alterations during the treatment, which includes morphological changes, ROS production, membrane potential and permeability, ETC activity and ATP production. Intriguingly, polysaccharides exhibit protective effects and maintain mitochondrial function on normal cells, while in cancer cells, polysaccharides tend to accelerate apoptosis and exacerbate mitochondrial dysfunction. Numerous signaling pathways, including antioxidant signaling pathway, anti-inflammatory signaling pathway and apoptotic signaling pathway are activated correspondingly. This review underlines the significance of the structural features of the polysaccharide, and thereafter indicates the modes of physiological function." @default.
- W4328131341 created "2023-03-22" @default.
- W4328131341 creator A5017391047 @default.
- W4328131341 creator A5023397464 @default.
- W4328131341 creator A5041331176 @default.
- W4328131341 creator A5043019475 @default.
- W4328131341 creator A5061756846 @default.
- W4328131341 creator A5079413655 @default.
- W4328131341 creator A5080141140 @default.
- W4328131341 creator A5080555330 @default.
- W4328131341 date "2023-03-21" @default.
- W4328131341 modified "2023-09-29" @default.
- W4328131341 title "An overview of biological functions of natural polysaccharides: influence factors, mitochondria and signaling pathways" @default.
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