Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328132084> ?p ?o ?g. }
- W4328132084 abstract "Abstract Since narrow-spectrum antibiotics specifically target the infection-causing organism, their negative side effects are reduced compared with their broad-spectrum counterparts. However, the design of these narrow-spectrum antibiotics requires accurate knowledge about drug targets in different microorganisms and their selectivity. Constraint-based metabolic models can provide this required knowledge using a mathematical framework for in-silico cell metabolism analysis and rewiring. Furthermore, competing against infectious pathogens, especially drug-resistant organisms, is more efficient by targeting multiple targets in each individual microorganism. Here, we combined the idea of synthetic lethality with selective drug targeting to obtain multi-target and organism-specific potential drug candidates for six different microorganisms and their various combinations. By considering each organism as targeted, conserved, or not included, we obtained 665 different cases for single essential reactions as well as double, triple, and quadruple synthetic lethal reaction sets. We found that conserving even one microorganism while attacking some targets reduces the number of potential cases tremendously. The number of solutions depends on how genomically far or close the microorganisms are in the phylogenetic tree. Furthermore, we statistically investigated how these potential drug targets attack different pathways in our studied cases, which reveals the importance of key routes such as cell envelope biosynthesis, glycerophospholipid metabolism, membrane lipid metabolism, and nucleotide salvage pathway." @default.
- W4328132084 created "2023-03-22" @default.
- W4328132084 creator A5024229365 @default.
- W4328132084 creator A5062228773 @default.
- W4328132084 creator A5065473983 @default.
- W4328132084 date "2023-03-21" @default.
- W4328132084 modified "2023-10-17" @default.
- W4328132084 title "Systematic analysis of microorganisms’ metabolism for selective targeting" @default.
- W4328132084 cites W191258721 @default.
- W4328132084 cites W1966423019 @default.
- W4328132084 cites W1988126896 @default.
- W4328132084 cites W1991980634 @default.
- W4328132084 cites W1994750157 @default.
- W4328132084 cites W2004340874 @default.
- W4328132084 cites W2017289276 @default.
- W4328132084 cites W2019096041 @default.
- W4328132084 cites W2046245796 @default.
- W4328132084 cites W2066918275 @default.
- W4328132084 cites W2072447308 @default.
- W4328132084 cites W2081492047 @default.
- W4328132084 cites W2091062253 @default.
- W4328132084 cites W2094491295 @default.
- W4328132084 cites W2117509624 @default.
- W4328132084 cites W2121404287 @default.
- W4328132084 cites W2128912763 @default.
- W4328132084 cites W2133510724 @default.
- W4328132084 cites W2140595402 @default.
- W4328132084 cites W2157589025 @default.
- W4328132084 cites W2175951661 @default.
- W4328132084 cites W2517088688 @default.
- W4328132084 cites W2563313380 @default.
- W4328132084 cites W2568352511 @default.
- W4328132084 cites W2592187601 @default.
- W4328132084 cites W2592321159 @default.
- W4328132084 cites W2741474903 @default.
- W4328132084 cites W2764202526 @default.
- W4328132084 cites W2766208300 @default.
- W4328132084 cites W2766902410 @default.
- W4328132084 cites W2767891136 @default.
- W4328132084 cites W2767992859 @default.
- W4328132084 cites W2797402052 @default.
- W4328132084 cites W2886325974 @default.
- W4328132084 cites W2888191331 @default.
- W4328132084 cites W2910227631 @default.
- W4328132084 cites W2912247484 @default.
- W4328132084 cites W2912479692 @default.
- W4328132084 cites W2927961455 @default.
- W4328132084 cites W3025519654 @default.
- W4328132084 cites W3042302441 @default.
- W4328132084 cites W3156773689 @default.
- W4328132084 cites W3158016107 @default.
- W4328132084 cites W3164153505 @default.
- W4328132084 cites W3209574976 @default.
- W4328132084 cites W4229456744 @default.
- W4328132084 cites W4284663268 @default.
- W4328132084 cites W4292488045 @default.
- W4328132084 doi "https://doi.org/10.21203/rs.3.rs-2670378/v1" @default.
- W4328132084 hasPublicationYear "2023" @default.
- W4328132084 type Work @default.
- W4328132084 citedByCount "0" @default.
- W4328132084 crossrefType "posted-content" @default.
- W4328132084 hasAuthorship W4328132084A5024229365 @default.
- W4328132084 hasAuthorship W4328132084A5062228773 @default.
- W4328132084 hasAuthorship W4328132084A5065473983 @default.
- W4328132084 hasBestOaLocation W43281320841 @default.
- W4328132084 hasConcept C104317684 @default.
- W4328132084 hasConcept C137858568 @default.
- W4328132084 hasConcept C175605896 @default.
- W4328132084 hasConcept C19843653 @default.
- W4328132084 hasConcept C2775905019 @default.
- W4328132084 hasConcept C523546767 @default.
- W4328132084 hasConcept C54355233 @default.
- W4328132084 hasConcept C55493867 @default.
- W4328132084 hasConcept C62231903 @default.
- W4328132084 hasConcept C70721500 @default.
- W4328132084 hasConcept C74187038 @default.
- W4328132084 hasConcept C86803240 @default.
- W4328132084 hasConceptScore W4328132084C104317684 @default.
- W4328132084 hasConceptScore W4328132084C137858568 @default.
- W4328132084 hasConceptScore W4328132084C175605896 @default.
- W4328132084 hasConceptScore W4328132084C19843653 @default.
- W4328132084 hasConceptScore W4328132084C2775905019 @default.
- W4328132084 hasConceptScore W4328132084C523546767 @default.
- W4328132084 hasConceptScore W4328132084C54355233 @default.
- W4328132084 hasConceptScore W4328132084C55493867 @default.
- W4328132084 hasConceptScore W4328132084C62231903 @default.
- W4328132084 hasConceptScore W4328132084C70721500 @default.
- W4328132084 hasConceptScore W4328132084C74187038 @default.
- W4328132084 hasConceptScore W4328132084C86803240 @default.
- W4328132084 hasLocation W43281320841 @default.
- W4328132084 hasOpenAccess W4328132084 @default.
- W4328132084 hasPrimaryLocation W43281320841 @default.
- W4328132084 hasRelatedWork W1973973036 @default.
- W4328132084 hasRelatedWork W2026904316 @default.
- W4328132084 hasRelatedWork W2035480884 @default.
- W4328132084 hasRelatedWork W2068905743 @default.
- W4328132084 hasRelatedWork W2083740430 @default.
- W4328132084 hasRelatedWork W2117066838 @default.
- W4328132084 hasRelatedWork W2902234465 @default.
- W4328132084 hasRelatedWork W4293662977 @default.